Recombinant Slit2 suppresses neuroinflammation and Cdc42-mediated brain infiltration of peripheral immune cells via Robo1–srGAP1 pathway in a rat model of germinal matrix hemorrhage

Recombinant Slit2 suppresses neuroinflammation and Cdc42-mediated brain infiltration of peripheral immune cells via Robo1–srGAP1 pathway in a rat model of germinal matrix hemorrhage

Abstract Background Germinal matrix hemorrhage (GMH) is a devastating neonatal stroke, in which neuroinflammation is a critical pathological contributor. Slit2, a secreted extracellular matrix protein, plays a repulsive role in axon guidance and leukocyte chemotaxis via the roundabout1 (Robo1) recep...

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Bibliographic Details
Main Authors: Qian Li, Lei Huang, Yan Ding, Prativa Sherchan, Wenjie Peng, John H. Zhang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Neuroinflammation
Subjects:
Germinal matrix hemorrhage
Slit2
Robo1–srGAP1
Neuroinflammation
Apoptosis
Rat
Online Access:https://doi.org/10.1186/s12974-023-02935-2

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