Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues
Epithelia are sheets of cells that communicate and coordinate their behavior in order to ensure their barrier function. Among the plethora of proteins involved in epithelial dynamics, actin nucleators play an essential role. The branched actin nucleation complex Arp2/3 has numerous functions, such a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.886288/full |
| _version_ | 1817988833670594560 |
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| author | Emmanuel Martin Emmanuel Martin Magali Suzanne Magali Suzanne |
| author_facet | Emmanuel Martin Emmanuel Martin Magali Suzanne Magali Suzanne |
| author_sort | Emmanuel Martin |
| collection | DOAJ |
| description | Epithelia are sheets of cells that communicate and coordinate their behavior in order to ensure their barrier function. Among the plethora of proteins involved in epithelial dynamics, actin nucleators play an essential role. The branched actin nucleation complex Arp2/3 has numerous functions, such as the regulation of cell-cell adhesion, intracellular trafficking, the formation of protrusions, that have been well described at the level of individual cells. Here, we chose to focus on its role in epithelial tissue, which is rising attention in recent works. We discuss how the cellular activities of the Arp2/3 complex drive epithelial dynamics and/or tissue morphogenesis. In the first part, we examined how this complex influences cell-cell cooperation at local scale in processes such as cell-cell fusion or cell corpses engulfment. In the second part, we summarized recent papers dealing with the impact of the Arp2/3 complex at larger scale, focusing on different morphogenetic events, including cell intercalation, epithelial tissue closure and epithelial folding. Altogether, this review highlights the central role of Arp2/3 in a diversity of epithelial tissue reorganization. |
| first_indexed | 2024-04-14T00:39:22Z |
| format | Article |
| id | doaj.art-360a534165a94bfaa3d6061441a298ff |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-14T00:39:22Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-360a534165a94bfaa3d6061441a298ff2022-12-22T02:22:14ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-04-011010.3389/fcell.2022.886288886288Functions of Arp2/3 Complex in the Dynamics of Epithelial TissuesEmmanuel Martin0Emmanuel Martin1Magali Suzanne2Magali Suzanne3Molecular, Cellular and Developmental Biology (MCD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Toulouse, FranceFR3743 Centre de Biologie Intégrative (CBI), Toulouse, FranceMolecular, Cellular and Developmental Biology (MCD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Toulouse, FranceFR3743 Centre de Biologie Intégrative (CBI), Toulouse, FranceEpithelia are sheets of cells that communicate and coordinate their behavior in order to ensure their barrier function. Among the plethora of proteins involved in epithelial dynamics, actin nucleators play an essential role. The branched actin nucleation complex Arp2/3 has numerous functions, such as the regulation of cell-cell adhesion, intracellular trafficking, the formation of protrusions, that have been well described at the level of individual cells. Here, we chose to focus on its role in epithelial tissue, which is rising attention in recent works. We discuss how the cellular activities of the Arp2/3 complex drive epithelial dynamics and/or tissue morphogenesis. In the first part, we examined how this complex influences cell-cell cooperation at local scale in processes such as cell-cell fusion or cell corpses engulfment. In the second part, we summarized recent papers dealing with the impact of the Arp2/3 complex at larger scale, focusing on different morphogenetic events, including cell intercalation, epithelial tissue closure and epithelial folding. Altogether, this review highlights the central role of Arp2/3 in a diversity of epithelial tissue reorganization.https://www.frontiersin.org/articles/10.3389/fcell.2022.886288/fullARP2/3 complexbranched actinepithelial dynamicsmorphogenesisactin networks interplay |
| spellingShingle | Emmanuel Martin Emmanuel Martin Magali Suzanne Magali Suzanne Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues Frontiers in Cell and Developmental Biology ARP2/3 complex branched actin epithelial dynamics morphogenesis actin networks interplay |
| title | Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues |
| title_full | Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues |
| title_fullStr | Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues |
| title_full_unstemmed | Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues |
| title_short | Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues |
| title_sort | functions of arp2 3 complex in the dynamics of epithelial tissues |
| topic | ARP2/3 complex branched actin epithelial dynamics morphogenesis actin networks interplay |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.886288/full |
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