Adenovirus Recruits Dynein by an Evolutionary Novel Mechanism Involving Direct Binding to pH-Primed Hexon
Following receptor-mediated uptake into endocytic vesicles and escape from the endosome, adenovirus is transported by cytoplasmic dynein along microtubules to the perinuclear region of the cell. How motor proteins are recruited to viruses for their own use has begun to be investigated only recently....
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2011-08-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/3/8/1417/ |
| _version_ | 1818837137233018880 |
|---|---|
| author | Julian Scherer Richard B Vallee |
| author_facet | Julian Scherer Richard B Vallee |
| author_sort | Julian Scherer |
| collection | DOAJ |
| description | Following receptor-mediated uptake into endocytic vesicles and escape from the endosome, adenovirus is transported by cytoplasmic dynein along microtubules to the perinuclear region of the cell. How motor proteins are recruited to viruses for their own use has begun to be investigated only recently. We review here the evidence for a role for dynein and other motor proteins in adenovirus infectivity. We also discuss the implications of recent studies on the mechanism of dynein recruitment to adenovirus for understanding the relationship between pathogenic and physiological cargo recruitment and for the evolutionary origins of dynein-mediated adenovirus transport. |
| first_indexed | 2024-12-19T03:17:43Z |
| format | Article |
| id | doaj.art-360b675c03cd4dc1aecd6f67e9b90391 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-19T03:17:43Z |
| publishDate | 2011-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-360b675c03cd4dc1aecd6f67e9b903912022-12-21T20:37:51ZengMDPI AGViruses1999-49152011-08-01381417143110.3390/v3081417Adenovirus Recruits Dynein by an Evolutionary Novel Mechanism Involving Direct Binding to pH-Primed HexonJulian SchererRichard B ValleeFollowing receptor-mediated uptake into endocytic vesicles and escape from the endosome, adenovirus is transported by cytoplasmic dynein along microtubules to the perinuclear region of the cell. How motor proteins are recruited to viruses for their own use has begun to be investigated only recently. We review here the evidence for a role for dynein and other motor proteins in adenovirus infectivity. We also discuss the implications of recent studies on the mechanism of dynein recruitment to adenovirus for understanding the relationship between pathogenic and physiological cargo recruitment and for the evolutionary origins of dynein-mediated adenovirus transport.http://www.mdpi.com/1999-4915/3/8/1417/adenovirusmolecular motorscytoplasmic dyneinintracellular motility |
| spellingShingle | Julian Scherer Richard B Vallee Adenovirus Recruits Dynein by an Evolutionary Novel Mechanism Involving Direct Binding to pH-Primed Hexon Viruses adenovirus molecular motors cytoplasmic dynein intracellular motility |
| title | Adenovirus Recruits Dynein by an Evolutionary Novel Mechanism Involving Direct Binding to pH-Primed Hexon |
| title_full | Adenovirus Recruits Dynein by an Evolutionary Novel Mechanism Involving Direct Binding to pH-Primed Hexon |
| title_fullStr | Adenovirus Recruits Dynein by an Evolutionary Novel Mechanism Involving Direct Binding to pH-Primed Hexon |
| title_full_unstemmed | Adenovirus Recruits Dynein by an Evolutionary Novel Mechanism Involving Direct Binding to pH-Primed Hexon |
| title_short | Adenovirus Recruits Dynein by an Evolutionary Novel Mechanism Involving Direct Binding to pH-Primed Hexon |
| title_sort | adenovirus recruits dynein by an evolutionary novel mechanism involving direct binding to ph primed hexon |
| topic | adenovirus molecular motors cytoplasmic dynein intracellular motility |
| url | http://www.mdpi.com/1999-4915/3/8/1417/ |
| work_keys_str_mv | AT julianscherer adenovirusrecruitsdyneinbyanevolutionarynovelmechanisminvolvingdirectbindingtophprimedhexon AT richardbvallee adenovirusrecruitsdyneinbyanevolutionarynovelmechanisminvolvingdirectbindingtophprimedhexon |