Reprogramming the lipid metabolism of dendritic cells in tumor immunomodulation and immunotherapy
Dendritic cells (DCs) are the most potent antigen-presenting cells in the human body. They detect and process environmental signals and communicate with T cells to bridge innate and adaptive immunity. Cell activation, function, and survival are closely associated with cellular metabolism. An increas...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223013720 |
| _version_ | 1797660496314236928 |
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| author | Zhanbo Sun Lingyun Zhang Lixian Liu |
| author_facet | Zhanbo Sun Lingyun Zhang Lixian Liu |
| author_sort | Zhanbo Sun |
| collection | DOAJ |
| description | Dendritic cells (DCs) are the most potent antigen-presenting cells in the human body. They detect and process environmental signals and communicate with T cells to bridge innate and adaptive immunity. Cell activation, function, and survival are closely associated with cellular metabolism. An increasing number of studies have revealed that lipid metabolism affects DC activation as well as innate and acquired immune responses. Combining lipid metabolic regulation with immunotherapy can strengthen the ability of antigen-presentation and T-cell activation of DCs, improve the existing anti-tumor therapy, and overcome the defects of DC-related therapies in the current stage, which has great potential in cancer therapy. This review summarizes the lipid metabolism of DCs under physiological conditions, analyzes the role of reprogramming the lipid metabolism of DCs in tumor immune regulation, and discusses potential immunotherapeutic strategies. |
| first_indexed | 2024-03-11T18:31:42Z |
| format | Article |
| id | doaj.art-360e4ed4178e4157a56b14ffb33f3eed |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T18:31:42Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-360e4ed4178e4157a56b14ffb33f3eed2023-10-13T11:03:11ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-11-01167115574Reprogramming the lipid metabolism of dendritic cells in tumor immunomodulation and immunotherapyZhanbo Sun0Lingyun Zhang1Lixian Liu2Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, ChinaDepartment of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China; Corresponding author.Dendritic cells (DCs) are the most potent antigen-presenting cells in the human body. They detect and process environmental signals and communicate with T cells to bridge innate and adaptive immunity. Cell activation, function, and survival are closely associated with cellular metabolism. An increasing number of studies have revealed that lipid metabolism affects DC activation as well as innate and acquired immune responses. Combining lipid metabolic regulation with immunotherapy can strengthen the ability of antigen-presentation and T-cell activation of DCs, improve the existing anti-tumor therapy, and overcome the defects of DC-related therapies in the current stage, which has great potential in cancer therapy. This review summarizes the lipid metabolism of DCs under physiological conditions, analyzes the role of reprogramming the lipid metabolism of DCs in tumor immune regulation, and discusses potential immunotherapeutic strategies.http://www.sciencedirect.com/science/article/pii/S0753332223013720Dendritic cellsLipid metabolismTumor microenvironmentTumor immunomodulationImmunotherapy |
| spellingShingle | Zhanbo Sun Lingyun Zhang Lixian Liu Reprogramming the lipid metabolism of dendritic cells in tumor immunomodulation and immunotherapy Biomedicine & Pharmacotherapy Dendritic cells Lipid metabolism Tumor microenvironment Tumor immunomodulation Immunotherapy |
| title | Reprogramming the lipid metabolism of dendritic cells in tumor immunomodulation and immunotherapy |
| title_full | Reprogramming the lipid metabolism of dendritic cells in tumor immunomodulation and immunotherapy |
| title_fullStr | Reprogramming the lipid metabolism of dendritic cells in tumor immunomodulation and immunotherapy |
| title_full_unstemmed | Reprogramming the lipid metabolism of dendritic cells in tumor immunomodulation and immunotherapy |
| title_short | Reprogramming the lipid metabolism of dendritic cells in tumor immunomodulation and immunotherapy |
| title_sort | reprogramming the lipid metabolism of dendritic cells in tumor immunomodulation and immunotherapy |
| topic | Dendritic cells Lipid metabolism Tumor microenvironment Tumor immunomodulation Immunotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223013720 |
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