Lifetime cannabis use and childhood trauma increase risk of psychosis in carriers of CNR1 genetic variants: findings from the STREAM study
Objectives: Gene-environment interactions increase the risk of psychosis. The objective of this study was to investigate gene-gene and gene-environment interactions in psychosis, including single nucleotide variants (SNVs) of dopamine-2 receptor (D2R), N-methyl-d-aspartate receptor (NMDAR), and can...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Psiquiatria (ABP)
2023-07-01
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| Series: | Brazilian Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462023000300226&lng=en&tlng=en |
| _version_ | 1797788036743823360 |
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| author | Camila Marcelino Loureiro Fabiana Corsi-Zuelli Helene Aparecida Fachim Rosana Shuhama Adrielle Martins de Oliveira Paulo Rossi Menezes Caroline F. Dalton Paulo Louzada-Junior Sintia Iole Belangero Fernanda Coeli-Lacchini Gavin P. Reynolds Riccardo Lacchini Cristina Marta Del-Ben |
| author_facet | Camila Marcelino Loureiro Fabiana Corsi-Zuelli Helene Aparecida Fachim Rosana Shuhama Adrielle Martins de Oliveira Paulo Rossi Menezes Caroline F. Dalton Paulo Louzada-Junior Sintia Iole Belangero Fernanda Coeli-Lacchini Gavin P. Reynolds Riccardo Lacchini Cristina Marta Del-Ben |
| author_sort | Camila Marcelino Loureiro |
| collection | DOAJ |
| description | Objectives: Gene-environment interactions increase the risk of psychosis. The objective of this study was to investigate gene-gene and gene-environment interactions in psychosis, including single nucleotide variants (SNVs) of dopamine-2 receptor (D2R), N-methyl-d-aspartate receptor (NMDAR), and cannabinoid receptor type 1 (CB1R), lifetime cannabis use, and childhood trauma. Methods: Twenty-three SNVs of genes encoding D2R (DRD2: rs1799978, rs7131056, rs6275), NMDAR (GRIN1: rs4880213, rs11146020; GRIN2A: rs1420040, rs11866328; GRIN2B: rs890, rs2098469, rs7298664), and CB1R (CNR1: rs806380, rs806379, rs1049353, rs6454674, rs1535255, rs2023239, rs12720071, rs6928499, rs806374, rs7766029, rs806378, rs10485170, rs9450898) were genotyped in 143 first-episode psychosis patients (FEPp) and 286 community-based controls by Illumina HumanCoreExome-24 BeadChip. Gene-gene and gene-environment associations were assessed using nonparametric Multifactor Dimensionality Reduction software. Results: Single-locus analyses among the 23 SNVs for psychosis and gene-gene interactions were not significant (p > 0.05 for all comparisons); however, both environmental risk factors showed an association with psychosis (p < 0.001). Moreover, gene-environment interactions were significant for an SNV in CNR1 and cannabis use. The best-performing model was the combination of CNR1 rs12720071 and lifetime cannabis use (p < 0.001), suggesting an increased risk of psychosis. Conclusion: Our study supports the hypothesis of gene-environment interactions for psychosis involving T-allele carriers of CNR1 SNVs, childhood trauma, and cannabis use. |
| first_indexed | 2024-03-13T01:30:50Z |
| format | Article |
| id | doaj.art-360ff7c6d1c14dd68c85411fba4c41c7 |
| institution | Directory Open Access Journal |
| issn | 1809-452X |
| language | English |
| last_indexed | 2024-03-13T01:30:50Z |
| publishDate | 2023-07-01 |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj.art-360ff7c6d1c14dd68c85411fba4c41c72023-07-04T07:46:04ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1809-452X2023-07-0145322623510.47626/1516-4446-2022-2882Lifetime cannabis use and childhood trauma increase risk of psychosis in carriers of CNR1 genetic variants: findings from the STREAM studyCamila Marcelino Loureirohttps://orcid.org/0000-0002-0239-5064Fabiana Corsi-Zuellihttps://orcid.org/0000-0001-9202-3987Helene Aparecida Fachimhttps://orcid.org/0000-0003-3818-3167Rosana Shuhamahttps://orcid.org/0000-0001-7626-7543Adrielle Martins de Oliveirahttps://orcid.org/0000-0003-0173-6872Paulo Rossi Menezeshttps://orcid.org/0000-0001-6330-3314Caroline F. Daltonhttps://orcid.org/0000-0002-1404-873XPaulo Louzada-Juniorhttps://orcid.org/0000-0003-2585-3870Sintia Iole Belangerohttps://orcid.org/0000-0002-2419-4351Fernanda Coeli-Lacchinihttps://orcid.org/0000-0001-6568-7497Gavin P. Reynoldshttps://orcid.org/0000-0001-9026-7726Riccardo Lacchinihttps://orcid.org/0000-0002-3738-2036Cristina Marta Del-Benhttps://orcid.org/0000-0003-0145-9975 Objectives: Gene-environment interactions increase the risk of psychosis. The objective of this study was to investigate gene-gene and gene-environment interactions in psychosis, including single nucleotide variants (SNVs) of dopamine-2 receptor (D2R), N-methyl-d-aspartate receptor (NMDAR), and cannabinoid receptor type 1 (CB1R), lifetime cannabis use, and childhood trauma. Methods: Twenty-three SNVs of genes encoding D2R (DRD2: rs1799978, rs7131056, rs6275), NMDAR (GRIN1: rs4880213, rs11146020; GRIN2A: rs1420040, rs11866328; GRIN2B: rs890, rs2098469, rs7298664), and CB1R (CNR1: rs806380, rs806379, rs1049353, rs6454674, rs1535255, rs2023239, rs12720071, rs6928499, rs806374, rs7766029, rs806378, rs10485170, rs9450898) were genotyped in 143 first-episode psychosis patients (FEPp) and 286 community-based controls by Illumina HumanCoreExome-24 BeadChip. Gene-gene and gene-environment associations were assessed using nonparametric Multifactor Dimensionality Reduction software. Results: Single-locus analyses among the 23 SNVs for psychosis and gene-gene interactions were not significant (p > 0.05 for all comparisons); however, both environmental risk factors showed an association with psychosis (p < 0.001). Moreover, gene-environment interactions were significant for an SNV in CNR1 and cannabis use. The best-performing model was the combination of CNR1 rs12720071 and lifetime cannabis use (p < 0.001), suggesting an increased risk of psychosis. Conclusion: Our study supports the hypothesis of gene-environment interactions for psychosis involving T-allele carriers of CNR1 SNVs, childhood trauma, and cannabis use.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462023000300226&lng=en&tlng=enCannabis usechildhood traumafirst-episode psychosissingle nucleotide variants |
| spellingShingle | Camila Marcelino Loureiro Fabiana Corsi-Zuelli Helene Aparecida Fachim Rosana Shuhama Adrielle Martins de Oliveira Paulo Rossi Menezes Caroline F. Dalton Paulo Louzada-Junior Sintia Iole Belangero Fernanda Coeli-Lacchini Gavin P. Reynolds Riccardo Lacchini Cristina Marta Del-Ben Lifetime cannabis use and childhood trauma increase risk of psychosis in carriers of CNR1 genetic variants: findings from the STREAM study Brazilian Journal of Psychiatry Cannabis use childhood trauma first-episode psychosis single nucleotide variants |
| title | Lifetime cannabis use and childhood trauma increase risk of psychosis in carriers of CNR1 genetic variants: findings from the STREAM study |
| title_full | Lifetime cannabis use and childhood trauma increase risk of psychosis in carriers of CNR1 genetic variants: findings from the STREAM study |
| title_fullStr | Lifetime cannabis use and childhood trauma increase risk of psychosis in carriers of CNR1 genetic variants: findings from the STREAM study |
| title_full_unstemmed | Lifetime cannabis use and childhood trauma increase risk of psychosis in carriers of CNR1 genetic variants: findings from the STREAM study |
| title_short | Lifetime cannabis use and childhood trauma increase risk of psychosis in carriers of CNR1 genetic variants: findings from the STREAM study |
| title_sort | lifetime cannabis use and childhood trauma increase risk of psychosis in carriers of cnr1 genetic variants findings from the stream study |
| topic | Cannabis use childhood trauma first-episode psychosis single nucleotide variants |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462023000300226&lng=en&tlng=en |
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