The connection between tricarboxylic acid cycle enzyme mutations and pseudohypoxic signaling in pheochromocytoma and paraganglioma

The connection between tricarboxylic acid cycle enzyme mutations and pseudohypoxic signaling in pheochromocytoma and paraganglioma

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors originating from chromaffin cells, holding significant clinical importance due to their capacity for excessive catecholamine secretion and associated cardiovascular complications. Roughly 80% of cases are associated with gen...

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Bibliographic Details
Main Authors: Yuxiong Wang, Bin Liu, Faping Li, Yanghe Zhang, Xin Gao, Yishu Wang, Honglan Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Endocrinology
Subjects:
pheochromocytoma
paraganglioma
pseudohypoxia
VHL/HIF axis
genetic mutations
tricarboxylic acid cycle
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1274239/full

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