Endocan serum levels in patients with low- and high-grade meningiomas: does this biomarker have an indicative role?
Abstract Background Meningiomas are one of the most common tumors of the brain and central nervous system. The key role of endocan in predicting tumor growth and prognosis has been shown for several types of cancers; however, this role in meningiomas has not been evaluated. In the current study, we...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-07-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
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| Online Access: | https://doi.org/10.1186/s41983-021-00346-9 |
| _version_ | 1818665475215720448 |
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| author | Mohammad Javad Fattahi Fatemeh Sedaghat Mahyar Malekzadeh Amir Ali Nejat Maryam Poostkar Yousef Saberi Mousa Taghipour Abbas Ghaderi |
| author_facet | Mohammad Javad Fattahi Fatemeh Sedaghat Mahyar Malekzadeh Amir Ali Nejat Maryam Poostkar Yousef Saberi Mousa Taghipour Abbas Ghaderi |
| author_sort | Mohammad Javad Fattahi |
| collection | DOAJ |
| description | Abstract Background Meningiomas are one of the most common tumors of the brain and central nervous system. The key role of endocan in predicting tumor growth and prognosis has been shown for several types of cancers; however, this role in meningiomas has not been evaluated. In the current study, we investigated the relationship between endocan serum levels with low- and high-grade meningiomas. Results The serum level of endocan in the group with meningiomas was 283.34 (242.09-358.70) pg/ml and in the control group was 250.29 (207.56-329.71) pg/ml respectively (P = 0.172). Afterwards, patients were divided into three different groups (grades I, II, and III) and compared to the control. The level of endocan in the group with grade I of meningioma showed no significant difference compared to control individuals (P = 0.86). When patients with grade II and grade III compared with the control group, endocan serum levels were statistically significant (P = 0.002, P < 0.001 respectively). Moreover, our findings showed that the different grades of meningiomas were statistically significant compared to each other (P < 0.001) regarding endocan serum levels, meaning that the higher the grade, the higher the endocan serum levels. Conclusion Our findings revealed that higher grades of meningioma had higher endocan serum levels, however, the role of endocan in pathogenesis or progression of this type of tumor requiring further exclusively assessment. |
| first_indexed | 2024-12-17T05:49:13Z |
| format | Article |
| id | doaj.art-3611282f2378467997d3df60790e9287 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-12-17T05:49:13Z |
| publishDate | 2021-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-3611282f2378467997d3df60790e92872022-12-21T22:01:13ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292021-07-015711610.1186/s41983-021-00346-9Endocan serum levels in patients with low- and high-grade meningiomas: does this biomarker have an indicative role?Mohammad Javad Fattahi0Fatemeh Sedaghat1Mahyar Malekzadeh2Amir Ali Nejat3Maryam Poostkar4Yousef Saberi5Mousa Taghipour6Abbas Ghaderi7Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical SciencesShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical SciencesShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical SciencesShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical SciencesShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical SciencesShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical SciencesDepartment of Neurosurgery, Shiraz University of Medical SciencesShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical SciencesAbstract Background Meningiomas are one of the most common tumors of the brain and central nervous system. The key role of endocan in predicting tumor growth and prognosis has been shown for several types of cancers; however, this role in meningiomas has not been evaluated. In the current study, we investigated the relationship between endocan serum levels with low- and high-grade meningiomas. Results The serum level of endocan in the group with meningiomas was 283.34 (242.09-358.70) pg/ml and in the control group was 250.29 (207.56-329.71) pg/ml respectively (P = 0.172). Afterwards, patients were divided into three different groups (grades I, II, and III) and compared to the control. The level of endocan in the group with grade I of meningioma showed no significant difference compared to control individuals (P = 0.86). When patients with grade II and grade III compared with the control group, endocan serum levels were statistically significant (P = 0.002, P < 0.001 respectively). Moreover, our findings showed that the different grades of meningiomas were statistically significant compared to each other (P < 0.001) regarding endocan serum levels, meaning that the higher the grade, the higher the endocan serum levels. Conclusion Our findings revealed that higher grades of meningioma had higher endocan serum levels, however, the role of endocan in pathogenesis or progression of this type of tumor requiring further exclusively assessment.https://doi.org/10.1186/s41983-021-00346-9Cancer biomarkerEndocanMeningiomas |
| spellingShingle | Mohammad Javad Fattahi Fatemeh Sedaghat Mahyar Malekzadeh Amir Ali Nejat Maryam Poostkar Yousef Saberi Mousa Taghipour Abbas Ghaderi Endocan serum levels in patients with low- and high-grade meningiomas: does this biomarker have an indicative role? The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Cancer biomarker Endocan Meningiomas |
| title | Endocan serum levels in patients with low- and high-grade meningiomas: does this biomarker have an indicative role? |
| title_full | Endocan serum levels in patients with low- and high-grade meningiomas: does this biomarker have an indicative role? |
| title_fullStr | Endocan serum levels in patients with low- and high-grade meningiomas: does this biomarker have an indicative role? |
| title_full_unstemmed | Endocan serum levels in patients with low- and high-grade meningiomas: does this biomarker have an indicative role? |
| title_short | Endocan serum levels in patients with low- and high-grade meningiomas: does this biomarker have an indicative role? |
| title_sort | endocan serum levels in patients with low and high grade meningiomas does this biomarker have an indicative role |
| topic | Cancer biomarker Endocan Meningiomas |
| url | https://doi.org/10.1186/s41983-021-00346-9 |
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