Association between CD133 expression and clinicopathological profile in colorectal cancer
Aim To investigate CD133 expression and its relationship to clinicopathological profile in colorectal cancer (CRC) patients. Methods This cross-sectional study was performed at the Internal Medicine Department, School of Medicine, Adam Malik General Hospital. The colorectal cancer tissue was taken...
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| Format: | Article |
| Language: | English |
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Medical Association of Zenica-Doboj Canton
2020-08-01
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| Series: | Medicinski Glasnik |
| Subjects: | |
| Online Access: | http://ljkzedo.ba/mgpdf/mg33/11_Ray_1106_A.pdf |
| _version_ | 1818970332553281536 |
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| author | Imelda Rey Agung Putra Dharma Lindarto Fauzi Yusuf |
| author_facet | Imelda Rey Agung Putra Dharma Lindarto Fauzi Yusuf |
| author_sort | Imelda Rey |
| collection | DOAJ |
| description | Aim To investigate CD133 expression and its relationship to clinicopathological profile in colorectal cancer (CRC) patients.
Methods This cross-sectional study was performed at the Internal Medicine Department, School of Medicine, Adam Malik General Hospital. The colorectal cancer tissue was taken from surgical resection and colonoscopy biopsy from CRC patients. Clinical profile was obtained by a questionnaire. Histopathology examination was done using hematoxylin and eosin staining. Immunohistochemistry (distribution score and intensity score) combined with ROC analysis were conducted to determine CD133 expression. An association between CD133 expression and clinicopathological profile was then analyzed.
Results Out of 118 patients, 690 (58.5%) were male. The high and low level of CD133 expression were found in 44 (37.3%) and 74 (62.7%) patients, respectively. No difference between gender, age, body mass index, hemoglobin, leucocytes, platelets, and histopathology with CD133 expression was found. There was a significant difference between CD133 and different CRC locations (p=0.002). CD133 expression was higher in the proximal colon than the rectum (p=0.002), and it was higher in the distal colon than the rectum (p=0.008), especially in terms of percentages of stained cancer cells (distribution score).
Conclusion CD133 expression was associated with the tumour location, but not with other clinicopathological factors. |
| first_indexed | 2024-12-20T14:34:48Z |
| format | Article |
| id | doaj.art-36113c8615ff42a7b4e617fffb41b709 |
| institution | Directory Open Access Journal |
| issn | 1840-0132 1840-2445 |
| language | English |
| last_indexed | 2024-12-20T14:34:48Z |
| publishDate | 2020-08-01 |
| publisher | Medical Association of Zenica-Doboj Canton |
| record_format | Article |
| series | Medicinski Glasnik |
| spelling | doaj.art-36113c8615ff42a7b4e617fffb41b7092022-12-21T19:37:30ZengMedical Association of Zenica-Doboj CantonMedicinski Glasnik1840-01321840-24452020-08-0117240240710.17392/1106-20Association between CD133 expression and clinicopathological profile in colorectal cancerImelda Rey0Agung Putra1Dharma Lindarto2Fauzi Yusuf3Department of Internal Medicine, School of Medicine, Universitas Sumatera Utara, Medan, IndonesiaStem Cell And Cancer Research (SCCR), School of Medicine, Sultan Agung Islamic University (UNISSULA), Semarang, Indonesia; Doctoral Department of Medical Science, School of Medicine, Universitas Sumatera Utara, Medan; Pathology Anatomy Department, School of Medicine, Sultan Agung Islamic University (UNISSULA), Semarang, IndonesiaDepartment of Internal Medicine, School of Medicine, Universitas Sumatera Utara, Medan; octoral Department of Medical Science, School of Medicine, Universitas Sumatera Utara, Medan, IndonesiaDoctoral Department of Medical Science, School of Medicine, Universitas Sumatera Utara, Medan; Internal Medicine Department, School of Medicine, Syiah Kuala Univeristy, Banda Aceh; IndonesiaAim To investigate CD133 expression and its relationship to clinicopathological profile in colorectal cancer (CRC) patients. Methods This cross-sectional study was performed at the Internal Medicine Department, School of Medicine, Adam Malik General Hospital. The colorectal cancer tissue was taken from surgical resection and colonoscopy biopsy from CRC patients. Clinical profile was obtained by a questionnaire. Histopathology examination was done using hematoxylin and eosin staining. Immunohistochemistry (distribution score and intensity score) combined with ROC analysis were conducted to determine CD133 expression. An association between CD133 expression and clinicopathological profile was then analyzed. Results Out of 118 patients, 690 (58.5%) were male. The high and low level of CD133 expression were found in 44 (37.3%) and 74 (62.7%) patients, respectively. No difference between gender, age, body mass index, hemoglobin, leucocytes, platelets, and histopathology with CD133 expression was found. There was a significant difference between CD133 and different CRC locations (p=0.002). CD133 expression was higher in the proximal colon than the rectum (p=0.002), and it was higher in the distal colon than the rectum (p=0.008), especially in terms of percentages of stained cancer cells (distribution score). Conclusion CD133 expression was associated with the tumour location, but not with other clinicopathological factors.http://ljkzedo.ba/mgpdf/mg33/11_Ray_1106_A.pdfcarcinomacolonimmunohistochemistryneoplastic stem cellsrectum |
| spellingShingle | Imelda Rey Agung Putra Dharma Lindarto Fauzi Yusuf Association between CD133 expression and clinicopathological profile in colorectal cancer Medicinski Glasnik carcinoma colon immunohistochemistry neoplastic stem cells rectum |
| title | Association between CD133 expression and clinicopathological profile in colorectal cancer |
| title_full | Association between CD133 expression and clinicopathological profile in colorectal cancer |
| title_fullStr | Association between CD133 expression and clinicopathological profile in colorectal cancer |
| title_full_unstemmed | Association between CD133 expression and clinicopathological profile in colorectal cancer |
| title_short | Association between CD133 expression and clinicopathological profile in colorectal cancer |
| title_sort | association between cd133 expression and clinicopathological profile in colorectal cancer |
| topic | carcinoma colon immunohistochemistry neoplastic stem cells rectum |
| url | http://ljkzedo.ba/mgpdf/mg33/11_Ray_1106_A.pdf |
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