Past, present and future of molecular and cellular oncology
In the last twenty years, the field of cellular and molecular oncology has been born and has moved its first steps, with an increasingly rapid pace. Hundreds of oncogenic and oncosuppressive signaling cascades have been characterized, facilitating the development of an ever more refined and variegat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00001/full |
| _version_ | 1818250042330316800 |
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| author | Lorenzo eGalluzzi Lorenzo eGalluzzi Lorenzo eGalluzzi Ilio eVitale Ilio eVitale Ilio eVitale Guido eKroemer Guido eKroemer Guido eKroemer Guido eKroemer Guido eKroemer |
| author_facet | Lorenzo eGalluzzi Lorenzo eGalluzzi Lorenzo eGalluzzi Ilio eVitale Ilio eVitale Ilio eVitale Guido eKroemer Guido eKroemer Guido eKroemer Guido eKroemer Guido eKroemer |
| author_sort | Lorenzo eGalluzzi |
| collection | DOAJ |
| description | In the last twenty years, the field of cellular and molecular oncology has been born and has moved its first steps, with an increasingly rapid pace. Hundreds of oncogenic and oncosuppressive signaling cascades have been characterized, facilitating the development of an ever more refined and variegated arsenal of diagnostic and therapeutic weapons. Furthermore, several cancer-specific features and processes have been identified that constitute promising therapeutic targets. For instance, it has been demonstrated that microRNAs can play a critical role in oncogenesis and tumor suppression. Moreover, it turned out that tumor cells frequently exhibit an extensive metabolic rewiring, can behave in a stem cell-like fashion (and hence sustain tumor growth), often constitutively activate stress response pathways that allow them to survive, can react to therapy by engaging in non-apoptotic cell death programs, and sometimes die while eliciting a tumor-specific immune response. In this Perspective article, we discuss the main issues generated by these discoveries that will be in the limelight of molecular and cellular oncology research for the next, hopefully few years. |
| first_indexed | 2024-12-12T15:46:06Z |
| format | Article |
| id | doaj.art-3617042f51894fbc8ee5d4cf614f17b6 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T15:46:06Z |
| publishDate | 2011-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3617042f51894fbc8ee5d4cf614f17b62022-12-22T00:19:46ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2011-03-01110.3389/fonc.2011.000019888Past, present and future of molecular and cellular oncologyLorenzo eGalluzzi0Lorenzo eGalluzzi1Lorenzo eGalluzzi2Ilio eVitale3Ilio eVitale4Ilio eVitale5Guido eKroemer6Guido eKroemer7Guido eKroemer8Guido eKroemer9Guido eKroemer10INSERMInstitut Gustave RoussyUniversité Paris-SudINSERMInstitut Gustave RoussyUniversité Paris-SudINSERMInstitut Gustave RoussyCentre de Recherche des CordoliersHôpital Européen Georges PompidouUniversité Paris DescartesIn the last twenty years, the field of cellular and molecular oncology has been born and has moved its first steps, with an increasingly rapid pace. Hundreds of oncogenic and oncosuppressive signaling cascades have been characterized, facilitating the development of an ever more refined and variegated arsenal of diagnostic and therapeutic weapons. Furthermore, several cancer-specific features and processes have been identified that constitute promising therapeutic targets. For instance, it has been demonstrated that microRNAs can play a critical role in oncogenesis and tumor suppression. Moreover, it turned out that tumor cells frequently exhibit an extensive metabolic rewiring, can behave in a stem cell-like fashion (and hence sustain tumor growth), often constitutively activate stress response pathways that allow them to survive, can react to therapy by engaging in non-apoptotic cell death programs, and sometimes die while eliciting a tumor-specific immune response. In this Perspective article, we discuss the main issues generated by these discoveries that will be in the limelight of molecular and cellular oncology research for the next, hopefully few years.http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00001/fullApoptosiscancer stem cellsImmunogenic cell deathnecroptosisnon-oncogene addictionOncometabolites |
| spellingShingle | Lorenzo eGalluzzi Lorenzo eGalluzzi Lorenzo eGalluzzi Ilio eVitale Ilio eVitale Ilio eVitale Guido eKroemer Guido eKroemer Guido eKroemer Guido eKroemer Guido eKroemer Past, present and future of molecular and cellular oncology Frontiers in Oncology Apoptosis cancer stem cells Immunogenic cell death necroptosis non-oncogene addiction Oncometabolites |
| title | Past, present and future of molecular and cellular oncology |
| title_full | Past, present and future of molecular and cellular oncology |
| title_fullStr | Past, present and future of molecular and cellular oncology |
| title_full_unstemmed | Past, present and future of molecular and cellular oncology |
| title_short | Past, present and future of molecular and cellular oncology |
| title_sort | past present and future of molecular and cellular oncology |
| topic | Apoptosis cancer stem cells Immunogenic cell death necroptosis non-oncogene addiction Oncometabolites |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00001/full |
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