In vivo validation of highly customized cranial Ti-6AL-4V ELI prostheses fabricated through incremental forming and superplastic forming: an ovine model study
Abstract Cranial reconstructions are essential for restoring both function and aesthetics in patients with craniofacial deformities or traumatic injuries. Titanium prostheses have gained popularity due to their biocompatibility, strength, and corrosion resistance. The use of Superplastic Forming (SP...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
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Nature Portfolio
2024-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-57629-3 |
| _version_ | 1827291633470668800 |
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| author | Silvia Brogini Alberto Crovace Antonio Piccininni Giuseppe Serratore Gregorio Marchiori Melania Maglio Pasquale Guglielmi Angela Cusanno Luigi De Napoli Romina Conte Milena Fini Giuseppina Ambrogio Gianfranco Palumbo Gianluca Giavaresi |
| author_facet | Silvia Brogini Alberto Crovace Antonio Piccininni Giuseppe Serratore Gregorio Marchiori Melania Maglio Pasquale Guglielmi Angela Cusanno Luigi De Napoli Romina Conte Milena Fini Giuseppina Ambrogio Gianfranco Palumbo Gianluca Giavaresi |
| author_sort | Silvia Brogini |
| collection | DOAJ |
| description | Abstract Cranial reconstructions are essential for restoring both function and aesthetics in patients with craniofacial deformities or traumatic injuries. Titanium prostheses have gained popularity due to their biocompatibility, strength, and corrosion resistance. The use of Superplastic Forming (SPF) and Single Point Incremental Forming (SPIF) techniques to create titanium prostheses, specifically designed for cranial reconstructions was investigated in an ovine model through microtomographic and histomorphometric analyses. The results obtained from the explanted specimens revealed significant variations in bone volume, trabecular thickness, spacing, and number across different regions of interest (VOIs or ROIs). Those regions next to the center of the cranial defect exhibited the most immature bone, characterized by higher porosity, decreased trabecular thickness, and wider trabecular spacing. Dynamic histomorphometry demonstrated differences in the mineralizing surface to bone surface ratio (MS/BS) and mineral apposition rate (MAR) depending on the timing of fluorochrome administration. A layer of connective tissue separated the prosthesis and the bone tissue. Overall, the study provided validation for the use of cranial prostheses made using SPF and SPIF techniques, offering insights into the processes of bone formation and remodeling in the implanted ovine model. |
| first_indexed | 2024-04-24T12:41:17Z |
| format | Article |
| id | doaj.art-3617c437d6394bfbaf86e136024e3c47 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T12:41:17Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-3617c437d6394bfbaf86e136024e3c472024-04-07T11:14:08ZengNature PortfolioScientific Reports2045-23222024-04-0114111710.1038/s41598-024-57629-3In vivo validation of highly customized cranial Ti-6AL-4V ELI prostheses fabricated through incremental forming and superplastic forming: an ovine model studySilvia Brogini0Alberto Crovace1Antonio Piccininni2Giuseppe Serratore3Gregorio Marchiori4Melania Maglio5Pasquale Guglielmi6Angela Cusanno7Luigi De Napoli8Romina Conte9Milena Fini10Giuseppina Ambrogio11Gianfranco Palumbo12Gianluca Giavaresi13Scienze e Tecnologie Chirurgiche, IRCCS Istituto Ortopedico RizzoliDipartimento di Medicina Veterinaria, Università di SassariDipartimento di Meccanica, Matematica e Management, Politecnico di BariDipartimento di Ingegneria Meccanica, Energetica e Gestionale, Università Della CalabriaScienze e Tecnologie Chirurgiche, IRCCS Istituto Ortopedico RizzoliScienze e Tecnologie Chirurgiche, IRCCS Istituto Ortopedico RizzoliDipartimento di Meccanica, Matematica e Management, Politecnico di BariDipartimento di Meccanica, Matematica e Management, Politecnico di BariDipartimento di Ingegneria Meccanica, Energetica e Gestionale, Università Della CalabriaDipartimento di Ingegneria Meccanica, Energetica e Gestionale, Università Della CalabriaDirezione Scientifica, IRCCS Istituto Ortopedico RizzoliDipartimento di Ingegneria Meccanica, Energetica e Gestionale, Università Della CalabriaDipartimento di Meccanica, Matematica e Management, Politecnico di BariScienze e Tecnologie Chirurgiche, IRCCS Istituto Ortopedico RizzoliAbstract Cranial reconstructions are essential for restoring both function and aesthetics in patients with craniofacial deformities or traumatic injuries. Titanium prostheses have gained popularity due to their biocompatibility, strength, and corrosion resistance. The use of Superplastic Forming (SPF) and Single Point Incremental Forming (SPIF) techniques to create titanium prostheses, specifically designed for cranial reconstructions was investigated in an ovine model through microtomographic and histomorphometric analyses. The results obtained from the explanted specimens revealed significant variations in bone volume, trabecular thickness, spacing, and number across different regions of interest (VOIs or ROIs). Those regions next to the center of the cranial defect exhibited the most immature bone, characterized by higher porosity, decreased trabecular thickness, and wider trabecular spacing. Dynamic histomorphometry demonstrated differences in the mineralizing surface to bone surface ratio (MS/BS) and mineral apposition rate (MAR) depending on the timing of fluorochrome administration. A layer of connective tissue separated the prosthesis and the bone tissue. Overall, the study provided validation for the use of cranial prostheses made using SPF and SPIF techniques, offering insights into the processes of bone formation and remodeling in the implanted ovine model.https://doi.org/10.1038/s41598-024-57629-3 |
| spellingShingle | Silvia Brogini Alberto Crovace Antonio Piccininni Giuseppe Serratore Gregorio Marchiori Melania Maglio Pasquale Guglielmi Angela Cusanno Luigi De Napoli Romina Conte Milena Fini Giuseppina Ambrogio Gianfranco Palumbo Gianluca Giavaresi In vivo validation of highly customized cranial Ti-6AL-4V ELI prostheses fabricated through incremental forming and superplastic forming: an ovine model study Scientific Reports |
| title | In vivo validation of highly customized cranial Ti-6AL-4V ELI prostheses fabricated through incremental forming and superplastic forming: an ovine model study |
| title_full | In vivo validation of highly customized cranial Ti-6AL-4V ELI prostheses fabricated through incremental forming and superplastic forming: an ovine model study |
| title_fullStr | In vivo validation of highly customized cranial Ti-6AL-4V ELI prostheses fabricated through incremental forming and superplastic forming: an ovine model study |
| title_full_unstemmed | In vivo validation of highly customized cranial Ti-6AL-4V ELI prostheses fabricated through incremental forming and superplastic forming: an ovine model study |
| title_short | In vivo validation of highly customized cranial Ti-6AL-4V ELI prostheses fabricated through incremental forming and superplastic forming: an ovine model study |
| title_sort | in vivo validation of highly customized cranial ti 6al 4v eli prostheses fabricated through incremental forming and superplastic forming an ovine model study |
| url | https://doi.org/10.1038/s41598-024-57629-3 |
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