RUNX1T1 function in cell fate
Abstract RUNX1T1 (Runt-related transcription factor 1, translocated to 1), a myeloid translocation gene (MTG) family member, is usually investigated as part of the fusion protein RUNX1-RUNX1T1 for its role in acute myeloid leukemia. In the main, by recruiting histone deacetylases, RUNX1T1 negatively...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-022-03074-w |
| _version_ | 1811222341921800192 |
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| author | Nan Hu Linqing Zou Cheng Wang Guoqi Song |
| author_facet | Nan Hu Linqing Zou Cheng Wang Guoqi Song |
| author_sort | Nan Hu |
| collection | DOAJ |
| description | Abstract RUNX1T1 (Runt-related transcription factor 1, translocated to 1), a myeloid translocation gene (MTG) family member, is usually investigated as part of the fusion protein RUNX1-RUNX1T1 for its role in acute myeloid leukemia. In the main, by recruiting histone deacetylases, RUNX1T1 negatively influences transcription, enabling it to regulate the proliferation and differentiation of hematopoietic progenitors. Moreover, the formation of blood vessels, neuronal differentiation, microglial activation following injury, and intestinal development all relate closely to the expression of RUNX1T1. Furthermore, through alternative splicing of RUNX1T1, short and long isoforms have been noted to mediate adipogenesis by balancing the differentiation and proliferation of adipocytes. In addition, RUNX1T1 plays wide-ranging and diverse roles in carcinoma as a biomarker, suppressor, or positive regulator of carcinogenesis, closely correlated to specific organs and dominant signaling pathways. The aim of this work was to investigate the structure of RUNX1T1, which contains four conserved nervy homolog domains, and to demonstrate crosstalk with the Notch signaling pathway. Moreover, we endeavored to illustrate the effects of RUNX1T1 on cell fate from multiple aspects, including its influence on hematopoiesis, neuronal differentiation, microglial activation, intestinal development, adipogenesis, angiogenesis, and carcinogenesis. |
| first_indexed | 2024-04-12T08:14:15Z |
| format | Article |
| id | doaj.art-3617f5c7ac5145c9b5e1aad411e83d15 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-12T08:14:15Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-3617f5c7ac5145c9b5e1aad411e83d152022-12-22T03:40:50ZengBMCStem Cell Research & Therapy1757-65122022-07-0113111010.1186/s13287-022-03074-wRUNX1T1 function in cell fateNan Hu0Linqing Zou1Cheng Wang2Guoqi Song3Department of Hematology, Affiliated Hospital and Medical School of Nantong UniversityDepartment of Human Anatomy, Jiangsu Key Laboratory of Neuroregeneration, Nantong UniversityDepartment of Human Anatomy, Jiangsu Key Laboratory of Neuroregeneration, Nantong UniversityDepartment of Hematology, Affiliated Hospital and Medical School of Nantong UniversityAbstract RUNX1T1 (Runt-related transcription factor 1, translocated to 1), a myeloid translocation gene (MTG) family member, is usually investigated as part of the fusion protein RUNX1-RUNX1T1 for its role in acute myeloid leukemia. In the main, by recruiting histone deacetylases, RUNX1T1 negatively influences transcription, enabling it to regulate the proliferation and differentiation of hematopoietic progenitors. Moreover, the formation of blood vessels, neuronal differentiation, microglial activation following injury, and intestinal development all relate closely to the expression of RUNX1T1. Furthermore, through alternative splicing of RUNX1T1, short and long isoforms have been noted to mediate adipogenesis by balancing the differentiation and proliferation of adipocytes. In addition, RUNX1T1 plays wide-ranging and diverse roles in carcinoma as a biomarker, suppressor, or positive regulator of carcinogenesis, closely correlated to specific organs and dominant signaling pathways. The aim of this work was to investigate the structure of RUNX1T1, which contains four conserved nervy homolog domains, and to demonstrate crosstalk with the Notch signaling pathway. Moreover, we endeavored to illustrate the effects of RUNX1T1 on cell fate from multiple aspects, including its influence on hematopoiesis, neuronal differentiation, microglial activation, intestinal development, adipogenesis, angiogenesis, and carcinogenesis.https://doi.org/10.1186/s13287-022-03074-wRUNX1T1Cell fateProgenitor cellsDevelopmentDifferentiation |
| spellingShingle | Nan Hu Linqing Zou Cheng Wang Guoqi Song RUNX1T1 function in cell fate Stem Cell Research & Therapy RUNX1T1 Cell fate Progenitor cells Development Differentiation |
| title | RUNX1T1 function in cell fate |
| title_full | RUNX1T1 function in cell fate |
| title_fullStr | RUNX1T1 function in cell fate |
| title_full_unstemmed | RUNX1T1 function in cell fate |
| title_short | RUNX1T1 function in cell fate |
| title_sort | runx1t1 function in cell fate |
| topic | RUNX1T1 Cell fate Progenitor cells Development Differentiation |
| url | https://doi.org/10.1186/s13287-022-03074-w |
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