Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues
Galectins comprise a family of soluble β-galactoside-binding proteins, which regulate a variety of key biological processes including cell growth, differentiation, survival, and death. This paper aims to address the current knowledge on the unique properties, regulation, and expression of the galect...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/12/1909 |
| _version_ | 1797506432533266432 |
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| author | Jennifer D. Kaminker Alexander V. Timoshenko |
| author_facet | Jennifer D. Kaminker Alexander V. Timoshenko |
| author_sort | Jennifer D. Kaminker |
| collection | DOAJ |
| description | Galectins comprise a family of soluble β-galactoside-binding proteins, which regulate a variety of key biological processes including cell growth, differentiation, survival, and death. This paper aims to address the current knowledge on the unique properties, regulation, and expression of the galectin-16 gene (<i>LGALS16</i>) in human cells and tissues. To date, there are limited studies on this galectin, with most focusing on its tissue specificity to the placenta. Here, we report the expression and 8-Br-cAMP-induced upregulation of <i>LGALS16</i> in two placental cell lines (BeWo and JEG-3) in the context of trophoblastic differentiation. In addition, we provide the results of a bioinformatics search for <i>LGALS16</i> using datasets available at GEO, Human Protein Atlas, and prediction tools for relevant transcription factors and miRNAs. Our findings indicate that <i>LGALS16</i> is detected by microarrays in diverse human cells/tissues and alters expression in association with cancer, diabetes, and brain diseases. Molecular mechanisms of the transcriptional and post-transcriptional regulation of <i>LGALS16</i> are also discussed based on the available bioinformatics resources. |
| first_indexed | 2024-03-10T04:32:34Z |
| format | Article |
| id | doaj.art-36197200613641fcb96f15c8be877381 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T04:32:34Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-36197200613641fcb96f15c8be8773812023-11-23T04:01:06ZengMDPI AGBiomolecules2218-273X2021-12-011112190910.3390/biom11121909Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and TissuesJennifer D. Kaminker0Alexander V. Timoshenko1Department of Biology, The University of Western Ontario, London, ON N6A 5B7, CanadaDepartment of Biology, The University of Western Ontario, London, ON N6A 5B7, CanadaGalectins comprise a family of soluble β-galactoside-binding proteins, which regulate a variety of key biological processes including cell growth, differentiation, survival, and death. This paper aims to address the current knowledge on the unique properties, regulation, and expression of the galectin-16 gene (<i>LGALS16</i>) in human cells and tissues. To date, there are limited studies on this galectin, with most focusing on its tissue specificity to the placenta. Here, we report the expression and 8-Br-cAMP-induced upregulation of <i>LGALS16</i> in two placental cell lines (BeWo and JEG-3) in the context of trophoblastic differentiation. In addition, we provide the results of a bioinformatics search for <i>LGALS16</i> using datasets available at GEO, Human Protein Atlas, and prediction tools for relevant transcription factors and miRNAs. Our findings indicate that <i>LGALS16</i> is detected by microarrays in diverse human cells/tissues and alters expression in association with cancer, diabetes, and brain diseases. Molecular mechanisms of the transcriptional and post-transcriptional regulation of <i>LGALS16</i> are also discussed based on the available bioinformatics resources.https://www.mdpi.com/2218-273X/11/12/1909galectin<i>LGALS16</i>placentabrain tissuescell differentiationtranscription factor |
| spellingShingle | Jennifer D. Kaminker Alexander V. Timoshenko Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues Biomolecules galectin <i>LGALS16</i> placenta brain tissues cell differentiation transcription factor |
| title | Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues |
| title_full | Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues |
| title_fullStr | Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues |
| title_full_unstemmed | Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues |
| title_short | Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues |
| title_sort | expression regulation and functions of the galectin 16 gene in human cells and tissues |
| topic | galectin <i>LGALS16</i> placenta brain tissues cell differentiation transcription factor |
| url | https://www.mdpi.com/2218-273X/11/12/1909 |
| work_keys_str_mv | AT jenniferdkaminker expressionregulationandfunctionsofthegalectin16geneinhumancellsandtissues AT alexandervtimoshenko expressionregulationandfunctionsofthegalectin16geneinhumancellsandtissues |