An Integrative Pan-Cancer Analysis of Kinesin Family Member C1 (KIFC1) in Human Tumors
Kinesin family member C1 (KIFC1) is a minus-end-directed motor protein that is critically involved in microtubule crosslinking and spindle formation. KIFC1 is essential for supernumerary centrosomes, and it is associated with the initiation and progression of cancers. In the present study, we initia...
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MDPI AG
2022-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/3/637 |
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| author | Hao Wu Yingjuan Duan Siming Gong Qiang Zhu Xuanyou Liu Zhenguo Liu |
| author_facet | Hao Wu Yingjuan Duan Siming Gong Qiang Zhu Xuanyou Liu Zhenguo Liu |
| author_sort | Hao Wu |
| collection | DOAJ |
| description | Kinesin family member C1 (KIFC1) is a minus-end-directed motor protein that is critically involved in microtubule crosslinking and spindle formation. KIFC1 is essential for supernumerary centrosomes, and it is associated with the initiation and progression of cancers. In the present study, we initially reviewed the The Cancer Genome Atlas database and observed that <i>KIFC1</i> is abundantly expressed in most types of tumors. We then analyzed the gene alteration profiles, protein expressions, prognoses, and immune reactivities of KIFC1 in more than 10,000 samples from several well-established databases. In addition, we conducted a gene set enrichment analysis to investigate the potential mechanisms for the roles of <i>KIFC1</i> in carcinogenesis. The pan-cancer analysis of KIFC1 demonstrates significant statistical correlations of the KIFC1 expression with the clinical prognoses, the oncogenic signature gene sets, the myeloid-derived suppressor cell infiltration, the ImmunoScore, the immune checkpoints, the microsatellite instabilities, and the tumor mutational burdens across multiple tumors. These data may provide important information on the understanding of the role and mechanisms of KIFC1 in carcinogenesis and immunotherapy, as well as on the clinical progression of a variety of cancers. |
| first_indexed | 2024-03-09T20:05:38Z |
| format | Article |
| id | doaj.art-3619acee362f483c933e832eeb01ac0f |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:05:38Z |
| publishDate | 2022-03-01 |
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| series | Biomedicines |
| spelling | doaj.art-3619acee362f483c933e832eeb01ac0f2023-11-24T00:33:09ZengMDPI AGBiomedicines2227-90592022-03-0110363710.3390/biomedicines10030637An Integrative Pan-Cancer Analysis of Kinesin Family Member C1 (KIFC1) in Human TumorsHao Wu0Yingjuan Duan1Siming Gong2Qiang Zhu3Xuanyou Liu4Zhenguo Liu5Center for Precision Medicine and Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USAFaculty of Chemistry and Mineralogy, University of Leipzig, 04103 Leipzig, GermanyInstitute of Anatomy, University of Leipzig, 04103 Leipzig, GermanyCenter for Precision Medicine and Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USACenter for Precision Medicine and Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USACenter for Precision Medicine and Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USAKinesin family member C1 (KIFC1) is a minus-end-directed motor protein that is critically involved in microtubule crosslinking and spindle formation. KIFC1 is essential for supernumerary centrosomes, and it is associated with the initiation and progression of cancers. In the present study, we initially reviewed the The Cancer Genome Atlas database and observed that <i>KIFC1</i> is abundantly expressed in most types of tumors. We then analyzed the gene alteration profiles, protein expressions, prognoses, and immune reactivities of KIFC1 in more than 10,000 samples from several well-established databases. In addition, we conducted a gene set enrichment analysis to investigate the potential mechanisms for the roles of <i>KIFC1</i> in carcinogenesis. The pan-cancer analysis of KIFC1 demonstrates significant statistical correlations of the KIFC1 expression with the clinical prognoses, the oncogenic signature gene sets, the myeloid-derived suppressor cell infiltration, the ImmunoScore, the immune checkpoints, the microsatellite instabilities, and the tumor mutational burdens across multiple tumors. These data may provide important information on the understanding of the role and mechanisms of KIFC1 in carcinogenesis and immunotherapy, as well as on the clinical progression of a variety of cancers.https://www.mdpi.com/2227-9059/10/3/637KIFC1pan cancerprognosisMDSCsimmunotherapy |
| spellingShingle | Hao Wu Yingjuan Duan Siming Gong Qiang Zhu Xuanyou Liu Zhenguo Liu An Integrative Pan-Cancer Analysis of Kinesin Family Member C1 (KIFC1) in Human Tumors Biomedicines KIFC1 pan cancer prognosis MDSCs immunotherapy |
| title | An Integrative Pan-Cancer Analysis of Kinesin Family Member C1 (KIFC1) in Human Tumors |
| title_full | An Integrative Pan-Cancer Analysis of Kinesin Family Member C1 (KIFC1) in Human Tumors |
| title_fullStr | An Integrative Pan-Cancer Analysis of Kinesin Family Member C1 (KIFC1) in Human Tumors |
| title_full_unstemmed | An Integrative Pan-Cancer Analysis of Kinesin Family Member C1 (KIFC1) in Human Tumors |
| title_short | An Integrative Pan-Cancer Analysis of Kinesin Family Member C1 (KIFC1) in Human Tumors |
| title_sort | integrative pan cancer analysis of kinesin family member c1 kifc1 in human tumors |
| topic | KIFC1 pan cancer prognosis MDSCs immunotherapy |
| url | https://www.mdpi.com/2227-9059/10/3/637 |
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