Value of preoperative 18F-FDG PET/CT and HRCT in predicting the differentiation degree of lung adenocarcinoma dominated by solid density
Purpose To evaluate the value of positron emission tomography/computed tomography (PET/CT) combined with high-resolution CT (HRCT) in determining the degree of differentiation of lung adenocarcinoma. Methods From January 2018 to January 2022, 88 patients with solid density nodules that are lung aden...
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PeerJ Inc.
2023-04-01
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| author | Xiaolin Chen Ping Li Minghui Zhang Xuewei Wang Dalong Wang |
| author_facet | Xiaolin Chen Ping Li Minghui Zhang Xuewei Wang Dalong Wang |
| author_sort | Xiaolin Chen |
| collection | DOAJ |
| description | Purpose To evaluate the value of positron emission tomography/computed tomography (PET/CT) combined with high-resolution CT (HRCT) in determining the degree of differentiation of lung adenocarcinoma. Methods From January 2018 to January 2022, 88 patients with solid density nodules that are lung adenocarcinoma were surgically treated. All patients were examined using HRCT and PET/CT before surgery. During HRCT, two independent observers assessed the presence of lobulation, spiculation, pleural indentation, vascular convergence, and air bronchial signs (bronchial distortion and bronchial disruption). The diameter and CT value of the nodules were measured simultaneously. During PET/CT, the maximum standard uptake value (SUVmax), mean standard uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the nodules were measured. The risk factors of pathological classification were predicted by logistic regression analysis. Results All 88 patients (mean age 60 ± 8 years; 44 males and 44 females) were evaluated. The average nodule size was 2.6 ± 1.1 cm. The univariate analysis showed that carcinoembryonic antigen (CEA), pleural indentation, vascular convergence, bronchial distortion, and higher SUVmax were more common in poor differentiated lung adenocarcinoma, and in the multivariate analysis, pleural indentation, vascular convergence, and SUVmax were predictive factors. The combined diagnosis using these three factors showed that the area under the curve (AUC) was 0.735. Conclusion SUVmax >6.99 combined with HRCT (pleural indentation sign and vascular convergence sign) is helpful to predict the differentiation degree of lung adenocarcinoma dominated by solid density. |
| first_indexed | 2024-03-09T06:54:00Z |
| format | Article |
| id | doaj.art-3619ecf73c864e19b1d1ca92985ce54a |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:54:00Z |
| publishDate | 2023-04-01 |
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| spelling | doaj.art-3619ecf73c864e19b1d1ca92985ce54a2023-12-03T10:08:10ZengPeerJ Inc.PeerJ2167-83592023-04-0111e1524210.7717/peerj.15242Value of preoperative 18F-FDG PET/CT and HRCT in predicting the differentiation degree of lung adenocarcinoma dominated by solid densityXiaolin Chen0Ping Li1Minghui Zhang2Xuewei Wang3Dalong Wang4Department of PET/CT, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaDepartment of PET/CT, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of PET/CT, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaDepartment of PET/CT, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaPurpose To evaluate the value of positron emission tomography/computed tomography (PET/CT) combined with high-resolution CT (HRCT) in determining the degree of differentiation of lung adenocarcinoma. Methods From January 2018 to January 2022, 88 patients with solid density nodules that are lung adenocarcinoma were surgically treated. All patients were examined using HRCT and PET/CT before surgery. During HRCT, two independent observers assessed the presence of lobulation, spiculation, pleural indentation, vascular convergence, and air bronchial signs (bronchial distortion and bronchial disruption). The diameter and CT value of the nodules were measured simultaneously. During PET/CT, the maximum standard uptake value (SUVmax), mean standard uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the nodules were measured. The risk factors of pathological classification were predicted by logistic regression analysis. Results All 88 patients (mean age 60 ± 8 years; 44 males and 44 females) were evaluated. The average nodule size was 2.6 ± 1.1 cm. The univariate analysis showed that carcinoembryonic antigen (CEA), pleural indentation, vascular convergence, bronchial distortion, and higher SUVmax were more common in poor differentiated lung adenocarcinoma, and in the multivariate analysis, pleural indentation, vascular convergence, and SUVmax were predictive factors. The combined diagnosis using these three factors showed that the area under the curve (AUC) was 0.735. Conclusion SUVmax >6.99 combined with HRCT (pleural indentation sign and vascular convergence sign) is helpful to predict the differentiation degree of lung adenocarcinoma dominated by solid density.https://peerj.com/articles/15242.pdfLung adenocarcinomaPositron emission tomography/computed tomographySolid noduleHistological grade |
| spellingShingle | Xiaolin Chen Ping Li Minghui Zhang Xuewei Wang Dalong Wang Value of preoperative 18F-FDG PET/CT and HRCT in predicting the differentiation degree of lung adenocarcinoma dominated by solid density PeerJ Lung adenocarcinoma Positron emission tomography/computed tomography Solid nodule Histological grade |
| title | Value of preoperative 18F-FDG PET/CT and HRCT in predicting the differentiation degree of lung adenocarcinoma dominated by solid density |
| title_full | Value of preoperative 18F-FDG PET/CT and HRCT in predicting the differentiation degree of lung adenocarcinoma dominated by solid density |
| title_fullStr | Value of preoperative 18F-FDG PET/CT and HRCT in predicting the differentiation degree of lung adenocarcinoma dominated by solid density |
| title_full_unstemmed | Value of preoperative 18F-FDG PET/CT and HRCT in predicting the differentiation degree of lung adenocarcinoma dominated by solid density |
| title_short | Value of preoperative 18F-FDG PET/CT and HRCT in predicting the differentiation degree of lung adenocarcinoma dominated by solid density |
| title_sort | value of preoperative 18f fdg pet ct and hrct in predicting the differentiation degree of lung adenocarcinoma dominated by solid density |
| topic | Lung adenocarcinoma Positron emission tomography/computed tomography Solid nodule Histological grade |
| url | https://peerj.com/articles/15242.pdf |
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