Predictivity of stimulated serum thyroglobulin and antithyroglobulin antibodies for the efficacy of thyroid remnant ablation on patients with differentiated thyroid carcinoma
Differentiated thyroid cancers (DTC) are the most frequently occuring endocrine malignancies and accounts for ≥ 90% of all thyroid cancers. It was suggested that after total or near total thyroidectomy, the stimulated thyroglobuline (sTg) and quantified uptake in whole body scintigraphy (W...
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Society of Turaz Bilim
2016-12-01
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| Series: | Medicine Science |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=216984 |
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| author | Narin Nasiroglu Imga Serhat Isik Mehtap Navdar Basaran Bercem Aycicek Dogan Mazhar Muslum Tuna Mustafa Unal Dilek Berker Serdar Guler |
| author_facet | Narin Nasiroglu Imga Serhat Isik Mehtap Navdar Basaran Bercem Aycicek Dogan Mazhar Muslum Tuna Mustafa Unal Dilek Berker Serdar Guler |
| author_sort | Narin Nasiroglu Imga |
| collection | DOAJ |
| description | Differentiated thyroid cancers (DTC) are the most frequently occuring endocrine malignancies and accounts for ≥ 90% of all thyroid cancers. It was suggested that after total or near total thyroidectomy, the stimulated thyroglobuline (sTg) and quantified uptake in whole body scintigraphy (WBS) are significant predictors for the successful ablation and disease-free status. We aimed to evaluate preablative thyroid stimulating hormone (TSH), sTg and anti-thyroglobulin antibodies (TgAbs) levels, after following thyroid hormone withdrawal, and compare them with diagnostic WBS (DxWBS) uptake for predict the efficacy of radioiodine (RAI) ablation therapy in DTC patients. We retrospectively investigated 100 consecutively patients which followed up for DTC in Ankara Numune Education and Research Hospital at Department of Endocrinology and Metabolism between January 2006 and June 2013. Patients had histologically confirmed DTC and underwent RAI remnant ablation therapy without clinical or radiological evidence of distant metastases. 131I was used generally from 30-200 mCi dosage in all 100 patients. (median dose, 100 mCi). Preablation TSH, preablation sTg, postablation TSH, postablation sTg, postablation TgAbs levels, tumor size and tumor multifocality did not differ between DxWBS uptake negative and positive groups, while the preablation TgAbs level was found significantly lower in DxWBS uptake negative group (p [Med-Science 2016; 5(4.000): 961-6] |
| first_indexed | 2024-03-08T06:42:02Z |
| format | Article |
| id | doaj.art-361a556a264d4e718fa55f4bd7e0c3eb |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T06:42:02Z |
| publishDate | 2016-12-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-361a556a264d4e718fa55f4bd7e0c3eb2024-02-03T08:37:01ZengSociety of Turaz BilimMedicine Science2147-06342016-12-0154961610.5455/medscience.2016.05.8483216984Predictivity of stimulated serum thyroglobulin and antithyroglobulin antibodies for the efficacy of thyroid remnant ablation on patients with differentiated thyroid carcinomaNarin Nasiroglu Imga0Serhat Isik1Mehtap Navdar Basaran2Bercem Aycicek Dogan3Mazhar Muslum Tuna4Mustafa Unal5Dilek Berker6Serdar Guler7Ankara Numune Education and Research Hospital Department of Endocrinology, 06100, Ankara, Turkey Ankara Numune Education and Research Hospital Department of Endocrinology, 06100, Ankara, Turkey Ankara Numune Education and Research Hospital Department of Endocrinology, 06100, Ankara, Turkey Ankara Numune Education and Research Hospital Department of Endocrinology, 06100, Ankara, Turkey Ankara Numune Education and Research Hospital Department of Endocrinology, 06100, Ankara, Turkey Ankara Numune Education and Research Hospital Department of Endocrinology, 06100, Ankara, Turkey Ankara Numune Education and Research Hospital Department of Endocrinology, 06100, Ankara, Turkey Hitit University Faculty of Medicine Department of Endocrinology, 19100, Corum, TurkeyDifferentiated thyroid cancers (DTC) are the most frequently occuring endocrine malignancies and accounts for ≥ 90% of all thyroid cancers. It was suggested that after total or near total thyroidectomy, the stimulated thyroglobuline (sTg) and quantified uptake in whole body scintigraphy (WBS) are significant predictors for the successful ablation and disease-free status. We aimed to evaluate preablative thyroid stimulating hormone (TSH), sTg and anti-thyroglobulin antibodies (TgAbs) levels, after following thyroid hormone withdrawal, and compare them with diagnostic WBS (DxWBS) uptake for predict the efficacy of radioiodine (RAI) ablation therapy in DTC patients. We retrospectively investigated 100 consecutively patients which followed up for DTC in Ankara Numune Education and Research Hospital at Department of Endocrinology and Metabolism between January 2006 and June 2013. Patients had histologically confirmed DTC and underwent RAI remnant ablation therapy without clinical or radiological evidence of distant metastases. 131I was used generally from 30-200 mCi dosage in all 100 patients. (median dose, 100 mCi). Preablation TSH, preablation sTg, postablation TSH, postablation sTg, postablation TgAbs levels, tumor size and tumor multifocality did not differ between DxWBS uptake negative and positive groups, while the preablation TgAbs level was found significantly lower in DxWBS uptake negative group (p [Med-Science 2016; 5(4.000): 961-6]http://www.ejmanager.com/fulltextpdf.php?mno=216984differentiated thyroid cancersanti-thyroglobulin antibodies131i whole body scintigraphy |
| spellingShingle | Narin Nasiroglu Imga Serhat Isik Mehtap Navdar Basaran Bercem Aycicek Dogan Mazhar Muslum Tuna Mustafa Unal Dilek Berker Serdar Guler Predictivity of stimulated serum thyroglobulin and antithyroglobulin antibodies for the efficacy of thyroid remnant ablation on patients with differentiated thyroid carcinoma Medicine Science differentiated thyroid cancers anti-thyroglobulin antibodies 131i whole body scintigraphy |
| title | Predictivity of stimulated serum thyroglobulin and antithyroglobulin antibodies for the efficacy of thyroid remnant ablation on patients with differentiated
thyroid carcinoma |
| title_full | Predictivity of stimulated serum thyroglobulin and antithyroglobulin antibodies for the efficacy of thyroid remnant ablation on patients with differentiated
thyroid carcinoma |
| title_fullStr | Predictivity of stimulated serum thyroglobulin and antithyroglobulin antibodies for the efficacy of thyroid remnant ablation on patients with differentiated
thyroid carcinoma |
| title_full_unstemmed | Predictivity of stimulated serum thyroglobulin and antithyroglobulin antibodies for the efficacy of thyroid remnant ablation on patients with differentiated
thyroid carcinoma |
| title_short | Predictivity of stimulated serum thyroglobulin and antithyroglobulin antibodies for the efficacy of thyroid remnant ablation on patients with differentiated
thyroid carcinoma |
| title_sort | predictivity of stimulated serum thyroglobulin and antithyroglobulin antibodies for the efficacy of thyroid remnant ablation on patients with differentiated thyroid carcinoma |
| topic | differentiated thyroid cancers anti-thyroglobulin antibodies 131i whole body scintigraphy |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=216984 |
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