Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation
ObjectiveTo discuss the histological features, pathological types, and prognosis of gastric adenocarcinoma with mucinous differentiation.MethodsSpecimens of 189 cases of gastric adenocarcinoma with mucinous differentiation were collected for detailed histomorphology, immunohistochemistry, fluorescen...
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| Format: | Article |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.829702/full |
| _version_ | 1818909985683275776 |
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| author | Nian-Long Meng Yang-kun Wang Hai-Li Wang Jun-Ling Zhou Su-nan Wang |
| author_facet | Nian-Long Meng Yang-kun Wang Hai-Li Wang Jun-Ling Zhou Su-nan Wang |
| author_sort | Nian-Long Meng |
| collection | DOAJ |
| description | ObjectiveTo discuss the histological features, pathological types, and prognosis of gastric adenocarcinoma with mucinous differentiation.MethodsSpecimens of 189 cases of gastric adenocarcinoma with mucinous differentiation were collected for detailed histomorphology, immunohistochemistry, fluorescence in situ hybridization, and follow-up.ResultsIn accordance with the morphological and histological structural features of the cancer cells as well as the area ratio of the mucus, gastric adenocarcinoma with mucinous differentiation was divided into four types, namely pure mucinous carcinoma, intraductal papillary mucinous carcinoma, signet ring cell type mucinous carcinoma, and mixed cell type mucinous carcinoma. Based on the macroscopic types according to Bormann's classification, pure mucinous carcinoma was mostly Type I, intraductal papillary mucinous carcinoma was mostly Type II, signet ring cell type mucinous carcinoma was mostly Type IV, and mixed cell type mucinous carcinoma was mostly Type III. The 5-year survival rate was 69.2, 64.2, 0, and 31.5%, respectively. There was a statistical difference in the lymph node metastasis rate and survival rate of the four carcinoma types. The invasion features of pure mucinous carcinoma entailed penetrating corrosively in a push-in form, without blood vessel or lymphatic metastasis and with few lymphocytes and lymphatic nodules in the marginal area. Thus, there was little lymph node metastasis and invasion of nerves. The HER2 protein expression rate was 40.2% (76/189), the HER2 gene amplification detected by FISH technology was 16.9% (32/189).ConclusionThe independent histological type, four subtypes, and histopathological classification of gastric mucinous adenocarcinoma are important for the prognosis evaluation and precise treatment of this disease. |
| first_indexed | 2024-12-19T22:35:37Z |
| format | Article |
| id | doaj.art-361b488b0e1f4f63867255c9dd570744 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-19T22:35:37Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-361b488b0e1f4f63867255c9dd5707442022-12-21T20:03:13ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-03-01910.3389/fmed.2022.829702829702Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous DifferentiationNian-Long Meng0Yang-kun Wang1Hai-Li Wang2Jun-Ling Zhou3Su-nan Wang4Department of Pathology, 989th Hospital of the Joint Logistic Support Force of the PLA, Luoyang, ChinaDepartment of Pathology, Foresea Life Insurance Guangzhou General Hospital, Guangzhou, ChinaDepartment of Pathology, 989th Hospital of the Joint Logistic Support Force of the PLA, Luoyang, ChinaShenzhen Nanshan District People's Hospital, Shenzhen, ChinaShenzhen Polytechnic, Shenzhen, ChinaObjectiveTo discuss the histological features, pathological types, and prognosis of gastric adenocarcinoma with mucinous differentiation.MethodsSpecimens of 189 cases of gastric adenocarcinoma with mucinous differentiation were collected for detailed histomorphology, immunohistochemistry, fluorescence in situ hybridization, and follow-up.ResultsIn accordance with the morphological and histological structural features of the cancer cells as well as the area ratio of the mucus, gastric adenocarcinoma with mucinous differentiation was divided into four types, namely pure mucinous carcinoma, intraductal papillary mucinous carcinoma, signet ring cell type mucinous carcinoma, and mixed cell type mucinous carcinoma. Based on the macroscopic types according to Bormann's classification, pure mucinous carcinoma was mostly Type I, intraductal papillary mucinous carcinoma was mostly Type II, signet ring cell type mucinous carcinoma was mostly Type IV, and mixed cell type mucinous carcinoma was mostly Type III. The 5-year survival rate was 69.2, 64.2, 0, and 31.5%, respectively. There was a statistical difference in the lymph node metastasis rate and survival rate of the four carcinoma types. The invasion features of pure mucinous carcinoma entailed penetrating corrosively in a push-in form, without blood vessel or lymphatic metastasis and with few lymphocytes and lymphatic nodules in the marginal area. Thus, there was little lymph node metastasis and invasion of nerves. The HER2 protein expression rate was 40.2% (76/189), the HER2 gene amplification detected by FISH technology was 16.9% (32/189).ConclusionThe independent histological type, four subtypes, and histopathological classification of gastric mucinous adenocarcinoma are important for the prognosis evaluation and precise treatment of this disease.https://www.frontiersin.org/articles/10.3389/fmed.2022.829702/fullgastric neoplasmmucinous adenocarcinomamucinous differentiationhistopathologyimmunohistochemistry |
| spellingShingle | Nian-Long Meng Yang-kun Wang Hai-Li Wang Jun-Ling Zhou Su-nan Wang Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation Frontiers in Medicine gastric neoplasm mucinous adenocarcinoma mucinous differentiation histopathology immunohistochemistry |
| title | Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation |
| title_full | Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation |
| title_fullStr | Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation |
| title_full_unstemmed | Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation |
| title_short | Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation |
| title_sort | research on the histological features and pathological types of gastric adenocarcinoma with mucinous differentiation |
| topic | gastric neoplasm mucinous adenocarcinoma mucinous differentiation histopathology immunohistochemistry |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.829702/full |
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