Proteogenomic Approaches to Understand Gene Mutations and Protein Structural Alterations in Colon Cancer
With colon cancer being one of the deadliest and most common cancers, understanding the mechanisms behind colon cancer is crucial in improving therapies. One of the newest approaches in cancer research is the concept of proteogenomics. While genomic data is not sufficient to understand cancer, the i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Physiologia |
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| Online Access: | https://www.mdpi.com/2673-9488/3/1/2 |
| _version_ | 1797609410562883584 |
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| author | Soumyadev Sarkar |
| author_facet | Soumyadev Sarkar |
| author_sort | Soumyadev Sarkar |
| collection | DOAJ |
| description | With colon cancer being one of the deadliest and most common cancers, understanding the mechanisms behind colon cancer is crucial in improving therapies. One of the newest approaches in cancer research is the concept of proteogenomics. While genomic data is not sufficient to understand cancer, the integration of multi-omics data including proteomics in conjugation with protein modeling has a better potential to elucidate protein structural alterations and characterize tumors. This enables a more efficient diagnosis of cancer and improves remedial strategies. In this review, we aim to discuss the linkage between gene mutations and protein structural alterations that lead to colon cancer. Topics include alterations in the glycoproteome and structures of proteases that impact colon cancer development. Additionally, we highlight the importance of precision oncology with an emphasis on proteogenomic approaches, protein modeling, and the potential impact on colon cancer therapy. |
| first_indexed | 2024-03-11T06:01:00Z |
| format | Article |
| id | doaj.art-361bfeab3f204c93908fa0e55f08535c |
| institution | Directory Open Access Journal |
| issn | 2673-9488 |
| language | English |
| last_indexed | 2024-03-11T06:01:00Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Physiologia |
| spelling | doaj.art-361bfeab3f204c93908fa0e55f08535c2023-11-17T13:20:26ZengMDPI AGPhysiologia2673-94882023-01-0131112910.3390/physiologia3010002Proteogenomic Approaches to Understand Gene Mutations and Protein Structural Alterations in Colon CancerSoumyadev Sarkar0Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USAWith colon cancer being one of the deadliest and most common cancers, understanding the mechanisms behind colon cancer is crucial in improving therapies. One of the newest approaches in cancer research is the concept of proteogenomics. While genomic data is not sufficient to understand cancer, the integration of multi-omics data including proteomics in conjugation with protein modeling has a better potential to elucidate protein structural alterations and characterize tumors. This enables a more efficient diagnosis of cancer and improves remedial strategies. In this review, we aim to discuss the linkage between gene mutations and protein structural alterations that lead to colon cancer. Topics include alterations in the glycoproteome and structures of proteases that impact colon cancer development. Additionally, we highlight the importance of precision oncology with an emphasis on proteogenomic approaches, protein modeling, and the potential impact on colon cancer therapy.https://www.mdpi.com/2673-9488/3/1/2coloncolorectalcancerproteogenomicsproteinstructure |
| spellingShingle | Soumyadev Sarkar Proteogenomic Approaches to Understand Gene Mutations and Protein Structural Alterations in Colon Cancer Physiologia colon colorectal cancer proteogenomics protein structure |
| title | Proteogenomic Approaches to Understand Gene Mutations and Protein Structural Alterations in Colon Cancer |
| title_full | Proteogenomic Approaches to Understand Gene Mutations and Protein Structural Alterations in Colon Cancer |
| title_fullStr | Proteogenomic Approaches to Understand Gene Mutations and Protein Structural Alterations in Colon Cancer |
| title_full_unstemmed | Proteogenomic Approaches to Understand Gene Mutations and Protein Structural Alterations in Colon Cancer |
| title_short | Proteogenomic Approaches to Understand Gene Mutations and Protein Structural Alterations in Colon Cancer |
| title_sort | proteogenomic approaches to understand gene mutations and protein structural alterations in colon cancer |
| topic | colon colorectal cancer proteogenomics protein structure |
| url | https://www.mdpi.com/2673-9488/3/1/2 |
| work_keys_str_mv | AT soumyadevsarkar proteogenomicapproachestounderstandgenemutationsandproteinstructuralalterationsincoloncancer |