Menin–MLL1 Interaction Small Molecule Inhibitors: A Potential Therapeutic Strategy for Leukemia and Cancers

Menin–MLL1 Interaction Small Molecule Inhibitors: A Potential Therapeutic Strategy for Leukemia and Cancers

Encoded by the <i>MEN1</i> gene, menin protein is a fusion protein that is essential for the oncogenic transformation of mixed-lineage leukemia (MLL) and leads to acute leukemia (AL). Therefore, accumulating evidence has demonstrated that inhibition of the high-affinity relationship betw...

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Bibliographic Details
Main Authors: Qing Shi, Meiqi Xu, Zhijian Kang, Manjie Zhang, Yakun Luo
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
molecule inhibitor
menin-MLL1 complex
leukemia
cancer
therapeutics strategies
Online Access:https://www.mdpi.com/1420-3049/28/7/3026

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