Current Knowledge of Endolysosomal and Autophagy Defects in Hereditary Spastic Paraplegia

Current Knowledge of Endolysosomal and Autophagy Defects in Hereditary Spastic Paraplegia

Hereditary spastic paraplegia (HSP) refers to a group of neurological disorders involving the degeneration of motor neurons. Due to their clinical and genetic heterogeneity, finding common effective therapeutics is difficult. Therefore, a better understanding of the common pathological mechanisms is...

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Bibliographic Details
Main Authors: Liriopé Toupenet Marchesi, Marion Leblanc, Giovanni Stevanin
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
spastic paraplegia
lysosomes
autophagy
endosomes
Online Access:https://www.mdpi.com/2073-4409/10/7/1678

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