Multiple Roles for Chemokines in Neutrophil Biology
Chemokines are recognized as the most critical mediators for selective neutrophil recruitment during inflammatory conditions. Furthermore, they are considered fundamental regulators of neutrophil mobilization from the bone marrow (BM) to the bloodstream and for their homing back at the end of their...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01259/full |
| _version_ | 1818891643981398016 |
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| author | Arianna Capucetti Francesca Albano Francesca Albano Raffaella Bonecchi Raffaella Bonecchi |
| author_facet | Arianna Capucetti Francesca Albano Francesca Albano Raffaella Bonecchi Raffaella Bonecchi |
| author_sort | Arianna Capucetti |
| collection | DOAJ |
| description | Chemokines are recognized as the most critical mediators for selective neutrophil recruitment during inflammatory conditions. Furthermore, they are considered fundamental regulators of neutrophil mobilization from the bone marrow (BM) to the bloodstream and for their homing back at the end of their life for apoptosis and clearance. However, chemokines are also important mediators of neutrophil effector functions including oxidative burst, degranulation, neutrophil extracellular trap (NET)osis, and production of inflammatory mediators. Neutrophils have been historically considered as a homogeneous population. In recent years, several maturation stages and subsets with different phenotypic profiles and effector functions were described both in physiological and pathological conditions such as infections, autoimmunity, and cancer. The aim of this review is to give an overview of the current evidence regarding the role of chemokines and chemokine receptors in neutrophil biology, including their possible role in neutrophil maturation, differentiation, and in defining emerging neutrophil subsets. |
| first_indexed | 2024-12-19T17:44:05Z |
| format | Article |
| id | doaj.art-362170cef3ba401ba617e1474ae5ba58 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T17:44:05Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-362170cef3ba401ba617e1474ae5ba582022-12-21T20:12:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-07-011110.3389/fimmu.2020.01259533351Multiple Roles for Chemokines in Neutrophil BiologyArianna Capucetti0Francesca Albano1Francesca Albano2Raffaella Bonecchi3Raffaella Bonecchi4Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, ItalyDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, ItalyHumanitas Clinical and Research Center - IRCCS, Rozzano, ItalyDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, ItalyHumanitas Clinical and Research Center - IRCCS, Rozzano, ItalyChemokines are recognized as the most critical mediators for selective neutrophil recruitment during inflammatory conditions. Furthermore, they are considered fundamental regulators of neutrophil mobilization from the bone marrow (BM) to the bloodstream and for their homing back at the end of their life for apoptosis and clearance. However, chemokines are also important mediators of neutrophil effector functions including oxidative burst, degranulation, neutrophil extracellular trap (NET)osis, and production of inflammatory mediators. Neutrophils have been historically considered as a homogeneous population. In recent years, several maturation stages and subsets with different phenotypic profiles and effector functions were described both in physiological and pathological conditions such as infections, autoimmunity, and cancer. The aim of this review is to give an overview of the current evidence regarding the role of chemokines and chemokine receptors in neutrophil biology, including their possible role in neutrophil maturation, differentiation, and in defining emerging neutrophil subsets.https://www.frontiersin.org/article/10.3389/fimmu.2020.01259/fullatypical chemokine receptorschemokine receptorschemokinesneutrophilsneutrophil subpopulations |
| spellingShingle | Arianna Capucetti Francesca Albano Francesca Albano Raffaella Bonecchi Raffaella Bonecchi Multiple Roles for Chemokines in Neutrophil Biology Frontiers in Immunology atypical chemokine receptors chemokine receptors chemokines neutrophils neutrophil subpopulations |
| title | Multiple Roles for Chemokines in Neutrophil Biology |
| title_full | Multiple Roles for Chemokines in Neutrophil Biology |
| title_fullStr | Multiple Roles for Chemokines in Neutrophil Biology |
| title_full_unstemmed | Multiple Roles for Chemokines in Neutrophil Biology |
| title_short | Multiple Roles for Chemokines in Neutrophil Biology |
| title_sort | multiple roles for chemokines in neutrophil biology |
| topic | atypical chemokine receptors chemokine receptors chemokines neutrophils neutrophil subpopulations |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.01259/full |
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