rdHSV-CA8 non-opioid analgesic gene therapy decreases somatosensory neuronal excitability by activating Kv7 voltage-gated potassium channels

rdHSV-CA8 non-opioid analgesic gene therapy decreases somatosensory neuronal excitability by activating Kv7 voltage-gated potassium channels

Chronic pain is common and inadequately treated, making the development of safe and effective analgesics a high priority. Our previous data indicate that carbonic anhydrase-8 (CA8) expression in dorsal root ganglia (DRG) mediates analgesia via inhibition of neuronal ER inositol trisphosphate recepto...

Full description

Bibliographic Details
Main Authors: Munal B. Kandel, Gerald Z. Zhuang, William F. Goins, Marco Marzulli, Mingdi Zhang, Joseph C. Glorioso, Yuan Kang, Alexandra E. Levitt, Wai-Meng Kwok, Roy C. Levitt, Konstantinos D. Sarantopoulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
non-opioid analgesia from CA8 gene therapy
carbonic anhydrase-8
Kv7 voltage-gated potassium channels
neuronal excitability
afterhyperpolarization
replication defective herpes-1 virus
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1398839/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2024.1398839/full

Similar Items