Incidence and Risk Factors of the Secondary Skin Infections in Patients with Radiodermatitis
Objective: The aim of this prospective study was to investigate the incidence and risk factors of secondary infected radiodermatitis in patients receiving radiotherapy and to determine isolated microorganisms’ resistance profiles to different antimicrobial agents.Materials and Methods: The study com...
| المؤلفون الرئيسيون: | , , |
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| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
Atatürk University
2011-12-01
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| سلاسل: | Eurasian Journal of Medicine |
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://www.eajm.org/text.php3?id=412 |
| _version_ | 1827200410135298048 |
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| author | Ulku Altoparlak Ozlem Koca Timur Koca |
| author_facet | Ulku Altoparlak Ozlem Koca Timur Koca |
| author_sort | Ulku Altoparlak |
| collection | DOAJ |
| description | Objective: The aim of this prospective study was to investigate the incidence and risk factors of secondary infected radiodermatitis in patients receiving radiotherapy and to determine isolated microorganisms’ resistance profiles to different antimicrobial agents.Materials and Methods: The study comprised 62 patients admitted to the Regional Training and Research Hospital from January 2009 to January 2010. Radiodermatitis was graded according to the National Cancer Institute’s Common Toxicity Criteria version 3.0. Potential risk factors for secondary infection were recorded and evaluated by univariate and multivariate analyses.Results: In 62 patients, grade 1, 2, 3 and 4 radiodermatitis were observed in 33 (53.2%), 11 (17.7%), 8 (12.9%) and 10 (16.2%) patients, respectively. Skin infection secondary to radiodermatitis occurred in 14 patients (infected patients), 21.4%, 21.4% and 57.2% of whom had grade 2, 3 and 4 radiodermatitis, respectively. Forty-eight patients were found to be colonized with micoorganisms (colonized patients). In the univariate analysis, concurrent endocrine therapy and radiodermatitis grade differed significantly between infected and colonized patients (p<0.05). Multivariate analyses showed that the radiodermatitis grade was an independent risk factor for the acquisition of infection (p<0.05). The microbial pathogens isolated from patients with skin infection were seven methicillin-resistant coagulase-negative Staphylococcus (MRCNS) strains, three methicillin-resistant Staphylococcus aureus (MRSA) strains, two Candida sp., one methicillin-sensitive coagulase-negative Staphylococcus (MSCNS) strain and one methicillin-sensitive S. aureus (MSSA) strain. Staphylococci strains were more resistant to beta-lactam antibiotics. No glycopeptide resistance was found.Conclusion: The results of this study indicate that high-grade radiodermatitis leads to an increased risk for secondary infection of the skin with pathogens. |
| first_indexed | 2024-04-10T12:19:50Z |
| format | Article |
| id | doaj.art-3622444b6ec54257ba14469e53fb9d49 |
| institution | Directory Open Access Journal |
| issn | 1308-8734 1308-8742 |
| language | English |
| last_indexed | 2025-03-21T10:48:22Z |
| publishDate | 2011-12-01 |
| publisher | Atatürk University |
| record_format | Article |
| series | Eurasian Journal of Medicine |
| spelling | doaj.art-3622444b6ec54257ba14469e53fb9d492024-07-02T19:58:43ZengAtatürk UniversityEurasian Journal of Medicine1308-87341308-87422011-12-014303177181Incidence and Risk Factors of the Secondary Skin Infections in Patients with RadiodermatitisUlku AltoparlakOzlem KocaTimur KocaObjective: The aim of this prospective study was to investigate the incidence and risk factors of secondary infected radiodermatitis in patients receiving radiotherapy and to determine isolated microorganisms’ resistance profiles to different antimicrobial agents.Materials and Methods: The study comprised 62 patients admitted to the Regional Training and Research Hospital from January 2009 to January 2010. Radiodermatitis was graded according to the National Cancer Institute’s Common Toxicity Criteria version 3.0. Potential risk factors for secondary infection were recorded and evaluated by univariate and multivariate analyses.Results: In 62 patients, grade 1, 2, 3 and 4 radiodermatitis were observed in 33 (53.2%), 11 (17.7%), 8 (12.9%) and 10 (16.2%) patients, respectively. Skin infection secondary to radiodermatitis occurred in 14 patients (infected patients), 21.4%, 21.4% and 57.2% of whom had grade 2, 3 and 4 radiodermatitis, respectively. Forty-eight patients were found to be colonized with micoorganisms (colonized patients). In the univariate analysis, concurrent endocrine therapy and radiodermatitis grade differed significantly between infected and colonized patients (p<0.05). Multivariate analyses showed that the radiodermatitis grade was an independent risk factor for the acquisition of infection (p<0.05). The microbial pathogens isolated from patients with skin infection were seven methicillin-resistant coagulase-negative Staphylococcus (MRCNS) strains, three methicillin-resistant Staphylococcus aureus (MRSA) strains, two Candida sp., one methicillin-sensitive coagulase-negative Staphylococcus (MSCNS) strain and one methicillin-sensitive S. aureus (MSSA) strain. Staphylococci strains were more resistant to beta-lactam antibiotics. No glycopeptide resistance was found.Conclusion: The results of this study indicate that high-grade radiodermatitis leads to an increased risk for secondary infection of the skin with pathogens.http://www.eajm.org/text.php3?id=412ColonizationRadiodermatitisRisk factorsSecondary skin infection |
| spellingShingle | Ulku Altoparlak Ozlem Koca Timur Koca Incidence and Risk Factors of the Secondary Skin Infections in Patients with Radiodermatitis Eurasian Journal of Medicine Colonization Radiodermatitis Risk factors Secondary skin infection |
| title | Incidence and Risk Factors of the Secondary Skin Infections in Patients with Radiodermatitis |
| title_full | Incidence and Risk Factors of the Secondary Skin Infections in Patients with Radiodermatitis |
| title_fullStr | Incidence and Risk Factors of the Secondary Skin Infections in Patients with Radiodermatitis |
| title_full_unstemmed | Incidence and Risk Factors of the Secondary Skin Infections in Patients with Radiodermatitis |
| title_short | Incidence and Risk Factors of the Secondary Skin Infections in Patients with Radiodermatitis |
| title_sort | incidence and risk factors of the secondary skin infections in patients with radiodermatitis |
| topic | Colonization Radiodermatitis Risk factors Secondary skin infection |
| url | http://www.eajm.org/text.php3?id=412 |
| work_keys_str_mv | AT ulkualtoparlak incidenceandriskfactorsofthesecondaryskininfectionsinpatientswithradiodermatitis AT ozlemkoca incidenceandriskfactorsofthesecondaryskininfectionsinpatientswithradiodermatitis AT timurkoca incidenceandriskfactorsofthesecondaryskininfectionsinpatientswithradiodermatitis |