Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein

Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein

Abstract Background Progression of Alzheimer’s disease leads to synapse loss, neural network dysfunction and cognitive failure. Accumulation of protein aggregates and brain immune activation have triggering roles in synaptic failure but the neuronal mechanisms underlying synapse loss are unclear. On...

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Bibliographic Details
Main Authors: Austin Stoner, Li Fu, LaShae Nicholson, Chao Zheng, Takuya Toyonaga, Joshua Spurrier, Will Laird, Zhengxin Cai, Stephen M. Strittmatter
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Alzheimer’s Research & Therapy
Subjects:
Cellular prion protein
Alzheimer knock-in mouse
Transcriptomics
C1q
Synaptic tagging
SV2A PET
Online Access:https://doi.org/10.1186/s13195-023-01345-z

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