Conserved longitudinal alterations of anti-S-protein IgG subclasses in disease progression in initial ancestral Wuhan and vaccine breakthrough Delta infections

Conserved longitudinal alterations of anti-S-protein IgG subclasses in disease progression in initial ancestral Wuhan and vaccine breakthrough Delta infections

IntroductionCOVID-19 has a wide disease spectrum ranging from asymptomatic to severe. While humoral immune responses are critical in preventing infection, the immune mechanisms leading to severe disease, and the identification of biomarkers of disease progression and/or resolution of the infection r...

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Bibliographic Details
Main Authors: Yun Shan Goh, Siew-Wai Fong, Pei Xiang Hor, Siti Naqiah Amrun, Cheryl Yi-Pin Lee, Barnaby Edward Young, Po Ying Chia, Paul A. Tambyah, Shirin Kalimuddin, Surinder Pada, Seow-Yen Tan, Louisa Jin Sun, Mark I-Cheng Chen, Yee-Sin Leo, David C. Lye, Lisa F. P. Ng, Laurent Renia
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Microbiology
Subjects:
SARS-CoV-2
COVID-19
S protein
antibodies
IgG subclasses
severity
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1043049/full

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