Impact of Systemic Inflammatory Response Syndrome on Clinical, Echocardiographic, and Computed Tomographic Outcomes Among Patients Undergoing Transcatheter Aortic Valve Implantation
BackgroundSystemic inflammatory response syndrome (SIRS) is a systemic insult that has been described with many interventional cardiac procedures. The outcomes of patients undergoing transcatheter aortic valve implantation (TAVI) are thought to be influenced by this syndrome not only on short-term,...
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| Format: | Article |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.746774/full |
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| author | Tarek A. N. Ahmed Tarek A. N. Ahmed You-Jeong Ki You-Jung Choi Heba M. El-Naggar Heba M. El-Naggar Jeehoon Kang Jung-Kyu Han Han-Mo Yang Kyung Woo Park Hyun-Jae Kang Bon-Kwon Koo Hyo-Soo Kim |
| author_facet | Tarek A. N. Ahmed Tarek A. N. Ahmed You-Jeong Ki You-Jung Choi Heba M. El-Naggar Heba M. El-Naggar Jeehoon Kang Jung-Kyu Han Han-Mo Yang Kyung Woo Park Hyun-Jae Kang Bon-Kwon Koo Hyo-Soo Kim |
| author_sort | Tarek A. N. Ahmed |
| collection | DOAJ |
| description | BackgroundSystemic inflammatory response syndrome (SIRS) is a systemic insult that has been described with many interventional cardiac procedures. The outcomes of patients undergoing transcatheter aortic valve implantation (TAVI) are thought to be influenced by this syndrome not only on short-term, but also on long-term.ObjectiveWe assessed the association of SIRS to different clinical, echocardiographic, and computed tomographic (CT) outcomes after TAVI.MethodsTwo hundred and twenty-four consecutive patients undergoing TAVI were enrolled in this study. They were assessed for the occurrence of SIRS within the first 48 h after TAVI. Patients were followed-up for short- and long-term clinical outcomes. Serial echocardiographic follow-ups were conducted at 1-week, 6-months, and 1-year. CT follow-up at 1 year was recorded.ResultsEighty patients (36%) developed SIRS. Among different parameters, only pre-TAVI total leucocytic count (TLC), pre-TAVI heart rate, and post-TAVI systolic blood pressure independently predicted the occurrence of SIRS. The incidence of HALT was not significantly different between both groups, albeit higher among SIRS patients (p = 0.1) at 1-year CT follow-up. Both groups had similar patterns of LV recovery on serial echocardiography. Long-term follow-up showed that all-cause death, cardiac death, and re-admission for heart failure (HF) or acute coronary syndrome (ACS) were significantly more frequent among SIRS patients. Early safety and clinical efficacy outcomes were more frequently encountered in the SIRS group, while device-related events and time-related valve safety were comparable.ConclusionAlthough SIRS implies an early acute inflammatory status post-TAVI, yet its clinical sequelae seem to extend to long-term clinical outcomes. |
| first_indexed | 2024-12-13T13:21:30Z |
| format | Article |
| id | doaj.art-36266db524b5419cb5a7140cda61a6e9 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-13T13:21:30Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-36266db524b5419cb5a7140cda61a6e92022-12-21T23:44:23ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-02-01810.3389/fcvm.2021.746774746774Impact of Systemic Inflammatory Response Syndrome on Clinical, Echocardiographic, and Computed Tomographic Outcomes Among Patients Undergoing Transcatheter Aortic Valve ImplantationTarek A. N. Ahmed0Tarek A. N. Ahmed1You-Jeong Ki2You-Jung Choi3Heba M. El-Naggar4Heba M. El-Naggar5Jeehoon Kang6Jung-Kyu Han7Han-Mo Yang8Kyung Woo Park9Hyun-Jae Kang10Bon-Kwon Koo11Hyo-Soo Kim12Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, South KoreaDepartment of Cardiovascular Medicine, Assiut University Heart Hospital, Assiut, EgyptDepartment of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, South KoreaDepartment of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, South KoreaDepartment of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, South KoreaDepartment of Cardiovascular Medicine, Assiut University Heart Hospital, Assiut, EgyptDepartment of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, South KoreaDepartment of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, South KoreaDepartment of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, South KoreaDepartment of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, South KoreaDepartment of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, South KoreaDepartment of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, South KoreaDepartment of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, South KoreaBackgroundSystemic inflammatory response syndrome (SIRS) is a systemic insult that has been described with many interventional cardiac procedures. The outcomes of patients undergoing transcatheter aortic valve implantation (TAVI) are thought to be influenced by this syndrome not only on short-term, but also on long-term.ObjectiveWe assessed the association of SIRS to different clinical, echocardiographic, and computed tomographic (CT) outcomes after TAVI.MethodsTwo hundred and twenty-four consecutive patients undergoing TAVI were enrolled in this study. They were assessed for the occurrence of SIRS within the first 48 h after TAVI. Patients were followed-up for short- and long-term clinical outcomes. Serial echocardiographic follow-ups were conducted at 1-week, 6-months, and 1-year. CT follow-up at 1 year was recorded.ResultsEighty patients (36%) developed SIRS. Among different parameters, only pre-TAVI total leucocytic count (TLC), pre-TAVI heart rate, and post-TAVI systolic blood pressure independently predicted the occurrence of SIRS. The incidence of HALT was not significantly different between both groups, albeit higher among SIRS patients (p = 0.1) at 1-year CT follow-up. Both groups had similar patterns of LV recovery on serial echocardiography. Long-term follow-up showed that all-cause death, cardiac death, and re-admission for heart failure (HF) or acute coronary syndrome (ACS) were significantly more frequent among SIRS patients. Early safety and clinical efficacy outcomes were more frequently encountered in the SIRS group, while device-related events and time-related valve safety were comparable.ConclusionAlthough SIRS implies an early acute inflammatory status post-TAVI, yet its clinical sequelae seem to extend to long-term clinical outcomes.https://www.frontiersin.org/articles/10.3389/fcvm.2021.746774/fullsystemic inflammatory response syndromehypoattenuation leaflet thickeningtranscatheter aortic valve implantationsubclinical leaflet thrombosisinflammatory markers |
| spellingShingle | Tarek A. N. Ahmed Tarek A. N. Ahmed You-Jeong Ki You-Jung Choi Heba M. El-Naggar Heba M. El-Naggar Jeehoon Kang Jung-Kyu Han Han-Mo Yang Kyung Woo Park Hyun-Jae Kang Bon-Kwon Koo Hyo-Soo Kim Impact of Systemic Inflammatory Response Syndrome on Clinical, Echocardiographic, and Computed Tomographic Outcomes Among Patients Undergoing Transcatheter Aortic Valve Implantation Frontiers in Cardiovascular Medicine systemic inflammatory response syndrome hypoattenuation leaflet thickening transcatheter aortic valve implantation subclinical leaflet thrombosis inflammatory markers |
| title | Impact of Systemic Inflammatory Response Syndrome on Clinical, Echocardiographic, and Computed Tomographic Outcomes Among Patients Undergoing Transcatheter Aortic Valve Implantation |
| title_full | Impact of Systemic Inflammatory Response Syndrome on Clinical, Echocardiographic, and Computed Tomographic Outcomes Among Patients Undergoing Transcatheter Aortic Valve Implantation |
| title_fullStr | Impact of Systemic Inflammatory Response Syndrome on Clinical, Echocardiographic, and Computed Tomographic Outcomes Among Patients Undergoing Transcatheter Aortic Valve Implantation |
| title_full_unstemmed | Impact of Systemic Inflammatory Response Syndrome on Clinical, Echocardiographic, and Computed Tomographic Outcomes Among Patients Undergoing Transcatheter Aortic Valve Implantation |
| title_short | Impact of Systemic Inflammatory Response Syndrome on Clinical, Echocardiographic, and Computed Tomographic Outcomes Among Patients Undergoing Transcatheter Aortic Valve Implantation |
| title_sort | impact of systemic inflammatory response syndrome on clinical echocardiographic and computed tomographic outcomes among patients undergoing transcatheter aortic valve implantation |
| topic | systemic inflammatory response syndrome hypoattenuation leaflet thickening transcatheter aortic valve implantation subclinical leaflet thrombosis inflammatory markers |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.746774/full |
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