Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidenceResearch in context

Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidenceResearch in context

Summary: Background: Glioblastoma is one of the most devastating and incurable cancers due to its aggressive behaviour and lack of available therapies, being its overall-survival from diagnosis ∼14-months. Thus, identification of new therapeutic tools is urgently needed. Interestingly, metabolism-r...

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Main Authors: Antonio C. Fuentes-Fayos, Miguel E. G-García, Jesús M. Pérez-Gómez, Antonio J. Montero-Hidalgo, Julia Martín-Colom, Carlos Doval-Rosa, Cristóbal Blanco-Acevedo, Encarnación Torres, Álvaro Toledano-Delgado, Rafael Sánchez-Sánchez, Esther Peralbo-Santaella, Rosa M. Ortega-Salas, Juan M. Jiménez-Vacas, Manuel Tena-Sempere, Miguel López, Justo P. Castaño, Manuel D. Gahete, Juan Solivera, Raúl M. Luque
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:EBioMedicine
Subjects:
Glioblastoma
Metformin
Simvastatin
Senescence
Splicing
Telomere
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642300049X

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