| Summary: | Introduction: Metaplastic breast cancer (MBC) is a rare, aggressive breast malignancy accounting for less than 1% of all breast cancers. Treatment of metaplastic breast cancers challenging, as there are no MBC-specific breast cancer treatment protocols. Case Presentation: We present the case of a 60-year-old woman with a diagnosis of metastatic metaplastic breast cancer who presented with a symptomatic, fungating 12-cm left breast primary. She received hypofractionated palliative radiotherapy to the left breast to a total dose of 3663 cGy in 11 fractions, with significant clinical improvement documented at 3 and 6 months post-completion of radiation. Conclusion (or Discussion): There is a paucity of literature on the treatment of metaplastic breast cancer. The patient presented with a large, symptomatic breast primary which was palliatively treated with hypofractionated breast irradiation with significant clinical improvement. This case discusses the rare diagnosis of and available treatment options for metaplastic breast cancer. Clinicians should consider local therapy to improve symptoms arising from this rare primary malignancy.
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