Examining associations between MDMA/ecstasy and classic psychedelic use and impairments in social functioning in a U.S. adult sample
Abstract Impairment in social functioning is a common source of morbidity across many mental health disorders, yet there is a dearth of effective and easily implemented interventions to support social functioning. MDMA/ecstasy and classic psychedelics (psilocybin, LSD, peyote, mescaline) represent t...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29763-x |
| _version_ | 1811165917749444608 |
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| author | Grant Jones Joshua Lipson Erica Wang |
| author_facet | Grant Jones Joshua Lipson Erica Wang |
| author_sort | Grant Jones |
| collection | DOAJ |
| description | Abstract Impairment in social functioning is a common source of morbidity across many mental health disorders, yet there is a dearth of effective and easily implemented interventions to support social functioning. MDMA/ecstasy and classic psychedelics (psilocybin, LSD, peyote, mescaline) represent two potential treatments for impairments in social functioning, as evidence suggests these compounds may be supportive for alleviating social difficulties. Using a nationally representative sample of U.S. adults from the National Survey on Drug Use and Health (2015–2019) (N = 214,505), we used survey-weighted multivariable ordinal and logistic regression to examine the associations between lifetime use of the aforementioned compounds and impairments in social functioning in the past year. Lifetime MDMA/ecstasy use was associated with lowered odds of three of our four social impairment outcomes: difficulty dealing with strangers (aOR 0.92), difficulty participating in social activities (aOR 0.90), and being prevented from participating in social activities (aOR 0.84). Lifetime mescaline use was also associated with lowered odds of difficulty dealing with strangers (aOR 0.85). All other substances either shared no relationship with impairments in social functioning or conferred increased odds of our outcomes. Future experimental studies can assess whether these relationships are causal. |
| first_indexed | 2024-04-10T15:44:01Z |
| format | Article |
| id | doaj.art-362a4b77feaa499695bdf9660b68c32d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T15:44:01Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-362a4b77feaa499695bdf9660b68c32d2023-02-12T12:12:01ZengNature PortfolioScientific Reports2045-23222023-02-0113111110.1038/s41598-023-29763-xExamining associations between MDMA/ecstasy and classic psychedelic use and impairments in social functioning in a U.S. adult sampleGrant Jones0Joshua Lipson1Erica Wang2Department of Psychology, Harvard UniversityTeachers College, Columbia UniversityColgate UniversityAbstract Impairment in social functioning is a common source of morbidity across many mental health disorders, yet there is a dearth of effective and easily implemented interventions to support social functioning. MDMA/ecstasy and classic psychedelics (psilocybin, LSD, peyote, mescaline) represent two potential treatments for impairments in social functioning, as evidence suggests these compounds may be supportive for alleviating social difficulties. Using a nationally representative sample of U.S. adults from the National Survey on Drug Use and Health (2015–2019) (N = 214,505), we used survey-weighted multivariable ordinal and logistic regression to examine the associations between lifetime use of the aforementioned compounds and impairments in social functioning in the past year. Lifetime MDMA/ecstasy use was associated with lowered odds of three of our four social impairment outcomes: difficulty dealing with strangers (aOR 0.92), difficulty participating in social activities (aOR 0.90), and being prevented from participating in social activities (aOR 0.84). Lifetime mescaline use was also associated with lowered odds of difficulty dealing with strangers (aOR 0.85). All other substances either shared no relationship with impairments in social functioning or conferred increased odds of our outcomes. Future experimental studies can assess whether these relationships are causal.https://doi.org/10.1038/s41598-023-29763-x |
| spellingShingle | Grant Jones Joshua Lipson Erica Wang Examining associations between MDMA/ecstasy and classic psychedelic use and impairments in social functioning in a U.S. adult sample Scientific Reports |
| title | Examining associations between MDMA/ecstasy and classic psychedelic use and impairments in social functioning in a U.S. adult sample |
| title_full | Examining associations between MDMA/ecstasy and classic psychedelic use and impairments in social functioning in a U.S. adult sample |
| title_fullStr | Examining associations between MDMA/ecstasy and classic psychedelic use and impairments in social functioning in a U.S. adult sample |
| title_full_unstemmed | Examining associations between MDMA/ecstasy and classic psychedelic use and impairments in social functioning in a U.S. adult sample |
| title_short | Examining associations between MDMA/ecstasy and classic psychedelic use and impairments in social functioning in a U.S. adult sample |
| title_sort | examining associations between mdma ecstasy and classic psychedelic use and impairments in social functioning in a u s adult sample |
| url | https://doi.org/10.1038/s41598-023-29763-x |
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