Primary Angle Closure Glaucoma-associated Genetic Polymorphisms in Northeast Iran
Purpose: To evaluate the association of five different polymorphisms from a genome-wide-associated study with susceptibility to glaucoma in the northeast Iranian population. Methods: Hundred and thirty patients with primary angle closure glaucoma (PACG) and 130 healthy controls were genotyped...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Knowledge E
2020-02-01
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| Series: | Journal of Ophthalmic & Vision Research |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/jovr.v15i1.5942 |
| _version_ | 1811248863156109312 |
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| author | Ali Yousefian Saeed Shokoohi-Rad Mohammad Reza Abbaszadegan Dorsa Morshedi Rad Selma Zargari Saman Milanizadeh Negar Morovatdar Ramin Daneshvar |
| author_facet | Ali Yousefian Saeed Shokoohi-Rad Mohammad Reza Abbaszadegan Dorsa Morshedi Rad Selma Zargari Saman Milanizadeh Negar Morovatdar Ramin Daneshvar |
| author_sort | Ali Yousefian |
| collection | DOAJ |
| description | Purpose: To evaluate the association of five different polymorphisms from a genome-wide-associated study with susceptibility to glaucoma in the northeast Iranian population.
Methods: Hundred and thirty patients with primary angle closure glaucoma (PACG) and 130 healthy controls were genotyped for the polymorphic regions with the aid of tetra-amplification refractory mutation system-polymerase chain reaction. The association of these variants with the disease susceptibility was measured statistically with the logistic regression method.
Results: Hundred and thirty patients with PACG (53 males, 77 females) with a mean age of 64.5
±
6.2 years and 130 healthy control subjects (51 males, 79 females) with a mean age of 64.0
±
5.7 years were selected for evaluation. There was a significant association between rs3816415 (P = 0.005), rs736893 (P
<
0.001), rs7494379 (P
<
0.001), and rs1258267 (P = 0.02) with PACG susceptibility. This association could not be shown for rs3739821.
Conclusion: It was revealed that studied variants in GLIS3, EPDR1, FERMT2, and CHAT genes can contribute to the incidence of PACG. Additional studies in other populations are needed to evaluate DPM2-FAM102A. |
| first_indexed | 2024-04-12T15:36:29Z |
| format | Article |
| id | doaj.art-362c850ad18a47259a826a0a8b192055 |
| institution | Directory Open Access Journal |
| issn | 2008-322X |
| language | English |
| last_indexed | 2024-04-12T15:36:29Z |
| publishDate | 2020-02-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-362c850ad18a47259a826a0a8b1920552022-12-22T03:26:57ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2020-02-0115455210.18502/jovr.v15i1.5942Primary Angle Closure Glaucoma-associated Genetic Polymorphisms in Northeast IranAli Yousefian0Saeed Shokoohi-Rad1Mohammad Reza Abbaszadegan2Dorsa Morshedi Rad3Selma Zargari4Saman Milanizadeh5Negar Morovatdar6Ramin Daneshvar7Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranClinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranClinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranClinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranClinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranClinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranClinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranClinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranPurpose: To evaluate the association of five different polymorphisms from a genome-wide-associated study with susceptibility to glaucoma in the northeast Iranian population. Methods: Hundred and thirty patients with primary angle closure glaucoma (PACG) and 130 healthy controls were genotyped for the polymorphic regions with the aid of tetra-amplification refractory mutation system-polymerase chain reaction. The association of these variants with the disease susceptibility was measured statistically with the logistic regression method. Results: Hundred and thirty patients with PACG (53 males, 77 females) with a mean age of 64.5 ± 6.2 years and 130 healthy control subjects (51 males, 79 females) with a mean age of 64.0 ± 5.7 years were selected for evaluation. There was a significant association between rs3816415 (P = 0.005), rs736893 (P < 0.001), rs7494379 (P < 0.001), and rs1258267 (P = 0.02) with PACG susceptibility. This association could not be shown for rs3739821. Conclusion: It was revealed that studied variants in GLIS3, EPDR1, FERMT2, and CHAT genes can contribute to the incidence of PACG. Additional studies in other populations are needed to evaluate DPM2-FAM102A.https://doi.org/10.18502/jovr.v15i1.5942polymorphismprimary angle closure glaucomars3816415rs736893rs7494379rs1258267 |
| spellingShingle | Ali Yousefian Saeed Shokoohi-Rad Mohammad Reza Abbaszadegan Dorsa Morshedi Rad Selma Zargari Saman Milanizadeh Negar Morovatdar Ramin Daneshvar Primary Angle Closure Glaucoma-associated Genetic Polymorphisms in Northeast Iran Journal of Ophthalmic & Vision Research polymorphism primary angle closure glaucoma rs3816415 rs736893 rs7494379 rs1258267 |
| title | Primary Angle Closure Glaucoma-associated Genetic Polymorphisms in Northeast Iran |
| title_full | Primary Angle Closure Glaucoma-associated Genetic Polymorphisms in Northeast Iran |
| title_fullStr | Primary Angle Closure Glaucoma-associated Genetic Polymorphisms in Northeast Iran |
| title_full_unstemmed | Primary Angle Closure Glaucoma-associated Genetic Polymorphisms in Northeast Iran |
| title_short | Primary Angle Closure Glaucoma-associated Genetic Polymorphisms in Northeast Iran |
| title_sort | primary angle closure glaucoma associated genetic polymorphisms in northeast iran |
| topic | polymorphism primary angle closure glaucoma rs3816415 rs736893 rs7494379 rs1258267 |
| url | https://doi.org/10.18502/jovr.v15i1.5942 |
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