RNA modifications: importance in immune cell biology and related diseases
Abstract RNA modifications have become hot topics recently. By influencing RNA processes, including generation, transportation, function, and metabolization, they act as critical regulators of cell biology. The immune cell abnormality in human diseases is also a research focus and progressing rapidl...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-09-01
|
| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-022-01175-9 |
| _version_ | 1798001529093881856 |
|---|---|
| author | Lian Cui Rui Ma Jiangluyi Cai Chunyuan Guo Zeyu Chen Lingling Yao Yuanyuan Wang Rui Fan Xin Wang Yuling Shi |
| author_facet | Lian Cui Rui Ma Jiangluyi Cai Chunyuan Guo Zeyu Chen Lingling Yao Yuanyuan Wang Rui Fan Xin Wang Yuling Shi |
| author_sort | Lian Cui |
| collection | DOAJ |
| description | Abstract RNA modifications have become hot topics recently. By influencing RNA processes, including generation, transportation, function, and metabolization, they act as critical regulators of cell biology. The immune cell abnormality in human diseases is also a research focus and progressing rapidly these years. Studies have demonstrated that RNA modifications participate in the multiple biological processes of immune cells, including development, differentiation, activation, migration, and polarization, thereby modulating the immune responses and are involved in some immune related diseases. In this review, we present existing knowledge of the biological functions and underlying mechanisms of RNA modifications, including N 6-methyladenosine (m6A), 5-methylcytosine (m5C), N 1-methyladenosine (m1A), N 7-methylguanosine (m7G), N 4-acetylcytosine (ac4C), pseudouridine (Ψ), uridylation, and adenosine-to-inosine (A-to-I) RNA editing, and summarize their critical roles in immune cell biology. Via regulating the biological processes of immune cells, RNA modifications can participate in the pathogenesis of immune related diseases, such as cancers, infection, inflammatory and autoimmune diseases. We further highlight the challenges and future directions based on the existing knowledge. All in all, this review will provide helpful knowledge as well as novel ideas for the researchers in this area. |
| first_indexed | 2024-04-11T11:37:40Z |
| format | Article |
| id | doaj.art-362c87849b544969a96dc06a26b23021 |
| institution | Directory Open Access Journal |
| issn | 2059-3635 |
| language | English |
| last_indexed | 2024-04-11T11:37:40Z |
| publishDate | 2022-09-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj.art-362c87849b544969a96dc06a26b230212022-12-22T04:25:55ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352022-09-017112610.1038/s41392-022-01175-9RNA modifications: importance in immune cell biology and related diseasesLian Cui0Rui Ma1Jiangluyi Cai2Chunyuan Guo3Zeyu Chen4Lingling Yao5Yuanyuan Wang6Rui Fan7Xin Wang8Yuling Shi9Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of MedicineDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of MedicineDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of MedicineDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of MedicineDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of MedicineDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of MedicineDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of MedicineDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of MedicineDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of MedicineDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of MedicineAbstract RNA modifications have become hot topics recently. By influencing RNA processes, including generation, transportation, function, and metabolization, they act as critical regulators of cell biology. The immune cell abnormality in human diseases is also a research focus and progressing rapidly these years. Studies have demonstrated that RNA modifications participate in the multiple biological processes of immune cells, including development, differentiation, activation, migration, and polarization, thereby modulating the immune responses and are involved in some immune related diseases. In this review, we present existing knowledge of the biological functions and underlying mechanisms of RNA modifications, including N 6-methyladenosine (m6A), 5-methylcytosine (m5C), N 1-methyladenosine (m1A), N 7-methylguanosine (m7G), N 4-acetylcytosine (ac4C), pseudouridine (Ψ), uridylation, and adenosine-to-inosine (A-to-I) RNA editing, and summarize their critical roles in immune cell biology. Via regulating the biological processes of immune cells, RNA modifications can participate in the pathogenesis of immune related diseases, such as cancers, infection, inflammatory and autoimmune diseases. We further highlight the challenges and future directions based on the existing knowledge. All in all, this review will provide helpful knowledge as well as novel ideas for the researchers in this area.https://doi.org/10.1038/s41392-022-01175-9 |
| spellingShingle | Lian Cui Rui Ma Jiangluyi Cai Chunyuan Guo Zeyu Chen Lingling Yao Yuanyuan Wang Rui Fan Xin Wang Yuling Shi RNA modifications: importance in immune cell biology and related diseases Signal Transduction and Targeted Therapy |
| title | RNA modifications: importance in immune cell biology and related diseases |
| title_full | RNA modifications: importance in immune cell biology and related diseases |
| title_fullStr | RNA modifications: importance in immune cell biology and related diseases |
| title_full_unstemmed | RNA modifications: importance in immune cell biology and related diseases |
| title_short | RNA modifications: importance in immune cell biology and related diseases |
| title_sort | rna modifications importance in immune cell biology and related diseases |
| url | https://doi.org/10.1038/s41392-022-01175-9 |
| work_keys_str_mv | AT liancui rnamodificationsimportanceinimmunecellbiologyandrelateddiseases AT ruima rnamodificationsimportanceinimmunecellbiologyandrelateddiseases AT jiangluyicai rnamodificationsimportanceinimmunecellbiologyandrelateddiseases AT chunyuanguo rnamodificationsimportanceinimmunecellbiologyandrelateddiseases AT zeyuchen rnamodificationsimportanceinimmunecellbiologyandrelateddiseases AT linglingyao rnamodificationsimportanceinimmunecellbiologyandrelateddiseases AT yuanyuanwang rnamodificationsimportanceinimmunecellbiologyandrelateddiseases AT ruifan rnamodificationsimportanceinimmunecellbiologyandrelateddiseases AT xinwang rnamodificationsimportanceinimmunecellbiologyandrelateddiseases AT yulingshi rnamodificationsimportanceinimmunecellbiologyandrelateddiseases |