Dioscorea nipponica extracts enhance recovery from skeletal muscle atrophy by suppressing NF-κB expression
Saponin derived from natural extracts can alleviate muscle atrophy. Dioscorea nipponica Makino (DNM) is commonly used in herbal medicine and contains various steroidal saponins, although its efficacy and mechanisms of action for treating muscle atrophy remain unknown. Here, differentiated myoblast c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464620303339 |
| _version_ | 1818722927516844032 |
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| author | Ki-Sun Park Hye Jin Kim Joo Tae Hwang Byoung Seob Ko |
| author_facet | Ki-Sun Park Hye Jin Kim Joo Tae Hwang Byoung Seob Ko |
| author_sort | Ki-Sun Park |
| collection | DOAJ |
| description | Saponin derived from natural extracts can alleviate muscle atrophy. Dioscorea nipponica Makino (DNM) is commonly used in herbal medicine and contains various steroidal saponins, although its efficacy and mechanisms of action for treating muscle atrophy remain unknown. Here, differentiated myoblast cells treated with DNM showed increased MyoD and MyoG expression and effectively promoted muscle formation. DNM effectively inhibited muscle atrophy induced by tumor necrosis factor alpha (TNFα) monotherapy, and combination treatment with protodioscin and protogracillin (among the tested DNM constituents) showed a synergistic effect on differentiated myoblast cells. DNM and this combination repressed TNFα-induced increased MuRF1 and Atrogin1/MAFbx expression by inhibiting nuclear factor-kappa B (NF-κB) expression. DNM also effectively promoted the recovery of muscle formation in injured mice. Therefore, DNM and its multi-constituents can potentially be used as therapeutic agents for muscle-related diseases and represent prospective food supplements. |
| first_indexed | 2024-12-17T21:02:24Z |
| format | Article |
| id | doaj.art-362daaf665fc4c0eab69ea3148876101 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T21:02:24Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-362daaf665fc4c0eab69ea31488761012022-12-21T21:32:41ZengElsevierJournal of Functional Foods1756-46462020-10-0173104109Dioscorea nipponica extracts enhance recovery from skeletal muscle atrophy by suppressing NF-κB expressionKi-Sun Park0Hye Jin Kim1Joo Tae Hwang2Byoung Seob Ko3Korea Institute of Oriental Medicine, Daejeon 34054, Republic of KoreaKorea Institute of Oriental Medicine, Daejeon 34054, Republic of KoreaKorea Institute of Oriental Medicine, Daejeon 34054, Republic of KoreaCorresponding author.; Korea Institute of Oriental Medicine, Daejeon 34054, Republic of KoreaSaponin derived from natural extracts can alleviate muscle atrophy. Dioscorea nipponica Makino (DNM) is commonly used in herbal medicine and contains various steroidal saponins, although its efficacy and mechanisms of action for treating muscle atrophy remain unknown. Here, differentiated myoblast cells treated with DNM showed increased MyoD and MyoG expression and effectively promoted muscle formation. DNM effectively inhibited muscle atrophy induced by tumor necrosis factor alpha (TNFα) monotherapy, and combination treatment with protodioscin and protogracillin (among the tested DNM constituents) showed a synergistic effect on differentiated myoblast cells. DNM and this combination repressed TNFα-induced increased MuRF1 and Atrogin1/MAFbx expression by inhibiting nuclear factor-kappa B (NF-κB) expression. DNM also effectively promoted the recovery of muscle formation in injured mice. Therefore, DNM and its multi-constituents can potentially be used as therapeutic agents for muscle-related diseases and represent prospective food supplements.http://www.sciencedirect.com/science/article/pii/S1756464620303339Dioscorea nipponica MakinoProtodioscinProtogracillinMuscle atrophyMuscle differentiationNF-κB |
| spellingShingle | Ki-Sun Park Hye Jin Kim Joo Tae Hwang Byoung Seob Ko Dioscorea nipponica extracts enhance recovery from skeletal muscle atrophy by suppressing NF-κB expression Journal of Functional Foods Dioscorea nipponica Makino Protodioscin Protogracillin Muscle atrophy Muscle differentiation NF-κB |
| title | Dioscorea nipponica extracts enhance recovery from skeletal muscle atrophy by suppressing NF-κB expression |
| title_full | Dioscorea nipponica extracts enhance recovery from skeletal muscle atrophy by suppressing NF-κB expression |
| title_fullStr | Dioscorea nipponica extracts enhance recovery from skeletal muscle atrophy by suppressing NF-κB expression |
| title_full_unstemmed | Dioscorea nipponica extracts enhance recovery from skeletal muscle atrophy by suppressing NF-κB expression |
| title_short | Dioscorea nipponica extracts enhance recovery from skeletal muscle atrophy by suppressing NF-κB expression |
| title_sort | dioscorea nipponica extracts enhance recovery from skeletal muscle atrophy by suppressing nf κb expression |
| topic | Dioscorea nipponica Makino Protodioscin Protogracillin Muscle atrophy Muscle differentiation NF-κB |
| url | http://www.sciencedirect.com/science/article/pii/S1756464620303339 |
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