Interaction between Fokl polymorphism and vitamin D deficiency in the symptoms of mental disorders in adults: a population-based study
Abstract Mental disorders are intricate and multifaceted and encompass social, economic, environmental, and biological factors. This study aimed to explore the potential association between vitamin D deficiency and anxiety and depression symptoms in adults, considering the role of the vitamin D rece...
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| Format: | Article |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-57558-1 |
| _version_ | 1797247256128126976 |
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| author | Thaís da Silva Sabião Luiz Antônio Alves de Menezes-Júnior Aline Priscila Batista Samara Silva de Moura Adriana Lúcia Meireles Mariana Carvalho de Menezes George Luiz Lins Machado-Coelho Júlia Cristina Cardoso Carraro |
| author_facet | Thaís da Silva Sabião Luiz Antônio Alves de Menezes-Júnior Aline Priscila Batista Samara Silva de Moura Adriana Lúcia Meireles Mariana Carvalho de Menezes George Luiz Lins Machado-Coelho Júlia Cristina Cardoso Carraro |
| author_sort | Thaís da Silva Sabião |
| collection | DOAJ |
| description | Abstract Mental disorders are intricate and multifaceted and encompass social, economic, environmental, and biological factors. This study aimed to explore the potential association between vitamin D deficiency and anxiety and depression symptoms in adults, considering the role of the vitamin D receptor gene polymorphism FokI (rs2228570). This was a population-based cross-sectional study with stratified and cluster sampling, evaluating anxiety symptoms (AS) and depression symptoms (DS) in 1637 adults. Vitamin D levels were measured using electrochemiluminescence and were considered deficient when < 20 ng/mL in a healthy population or < 30 ng/mL in at-risk groups. Genotyping was performed using real-time polymerase chain reaction with TaqMan probes. The prevalence rates of AS, DS, and vitamin D deficiency were 23.5%, 15.8%, and 30.9%, respectively. No direct association was observed between vitamin D deficiency and AS or DS. However, interaction analysis revealed a combined effect of vitamin D deficiency and FokI for DS but not for AS. Individuals with vitamin deficiency and one or two copies of the altered allele of the FokI exhibited a higher prevalence of DS than individuals homozygous for the wild-type allele and vitamin D sufficiency. The interaction between vitamin D deficiency and the FokI polymorphism was associated with DS. |
| first_indexed | 2024-04-24T19:55:48Z |
| format | Article |
| id | doaj.art-362df0b8740a4d5aa5155118042e5f82 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T19:55:48Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-362df0b8740a4d5aa5155118042e5f822024-03-24T12:19:54ZengNature PortfolioScientific Reports2045-23222024-03-0114111110.1038/s41598-024-57558-1Interaction between Fokl polymorphism and vitamin D deficiency in the symptoms of mental disorders in adults: a population-based studyThaís da Silva Sabião0Luiz Antônio Alves de Menezes-Júnior1Aline Priscila Batista2Samara Silva de Moura3Adriana Lúcia Meireles4Mariana Carvalho de Menezes5George Luiz Lins Machado-Coelho6Júlia Cristina Cardoso Carraro7School of Nutrition, Postgraduate Program in Health and Nutrition, Research and Study Group on Nutrition and Public Health (GPENSC), Federal University of Ouro PretoSchool of Nutrition, Postgraduate Program in Health and Nutrition, Research and Study Group on Nutrition and Public Health (GPENSC), Federal University of Ouro PretoPostgraduate Program in Biological Sciences, Federal University of Ouro PretoSchool of Nutrition, Postgraduate Program in Health and Nutrition, Research and Study Group on Nutrition and Public Health (GPENSC), Federal University of Ouro PretoDepartment of Clinical and Social Nutrition, Research and Study Group on Nutrition and Public Health (GPENSC), School of Nutrition, Federal University of Ouro PretoDepartment of Clinical and Social Nutrition, Research and Study Group on Nutrition and Public Health (GPENSC), School of Nutrition, Federal University of Ouro PretoEpidemiology Laboratory, Medical School, Federal University of Ouro PretoDepartment of Clinical and Social Nutrition, Research and Study Group on Nutrition and Public Health (GPENSC), School of Nutrition, Federal University of Ouro PretoAbstract Mental disorders are intricate and multifaceted and encompass social, economic, environmental, and biological factors. This study aimed to explore the potential association between vitamin D deficiency and anxiety and depression symptoms in adults, considering the role of the vitamin D receptor gene polymorphism FokI (rs2228570). This was a population-based cross-sectional study with stratified and cluster sampling, evaluating anxiety symptoms (AS) and depression symptoms (DS) in 1637 adults. Vitamin D levels were measured using electrochemiluminescence and were considered deficient when < 20 ng/mL in a healthy population or < 30 ng/mL in at-risk groups. Genotyping was performed using real-time polymerase chain reaction with TaqMan probes. The prevalence rates of AS, DS, and vitamin D deficiency were 23.5%, 15.8%, and 30.9%, respectively. No direct association was observed between vitamin D deficiency and AS or DS. However, interaction analysis revealed a combined effect of vitamin D deficiency and FokI for DS but not for AS. Individuals with vitamin deficiency and one or two copies of the altered allele of the FokI exhibited a higher prevalence of DS than individuals homozygous for the wild-type allele and vitamin D sufficiency. The interaction between vitamin D deficiency and the FokI polymorphism was associated with DS.https://doi.org/10.1038/s41598-024-57558-1 |
| spellingShingle | Thaís da Silva Sabião Luiz Antônio Alves de Menezes-Júnior Aline Priscila Batista Samara Silva de Moura Adriana Lúcia Meireles Mariana Carvalho de Menezes George Luiz Lins Machado-Coelho Júlia Cristina Cardoso Carraro Interaction between Fokl polymorphism and vitamin D deficiency in the symptoms of mental disorders in adults: a population-based study Scientific Reports |
| title | Interaction between Fokl polymorphism and vitamin D deficiency in the symptoms of mental disorders in adults: a population-based study |
| title_full | Interaction between Fokl polymorphism and vitamin D deficiency in the symptoms of mental disorders in adults: a population-based study |
| title_fullStr | Interaction between Fokl polymorphism and vitamin D deficiency in the symptoms of mental disorders in adults: a population-based study |
| title_full_unstemmed | Interaction between Fokl polymorphism and vitamin D deficiency in the symptoms of mental disorders in adults: a population-based study |
| title_short | Interaction between Fokl polymorphism and vitamin D deficiency in the symptoms of mental disorders in adults: a population-based study |
| title_sort | interaction between fokl polymorphism and vitamin d deficiency in the symptoms of mental disorders in adults a population based study |
| url | https://doi.org/10.1038/s41598-024-57558-1 |
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