DCUN1D1 Is an Essential Regulator of Prostate Cancer Proliferation and Tumour Growth That Acts through Neddylation of Cullin 1, 3, 4A and 5 and Deregulation of Wnt/Catenin Pathway

DCUN1D1 Is an Essential Regulator of Prostate Cancer Proliferation and Tumour Growth That Acts through Neddylation of Cullin 1, 3, 4A and 5 and Deregulation of Wnt/Catenin Pathway

Defective in cullin neddylation 1 domain containing 1 (DCUN1D1) is an E3 ligase for the neddylation, a post-translational process similar to and occurring in parallel to ubiquitin proteasome pathway. Although established as an oncogene in a variety of squamous cell carcinomas, the precise role of DC...

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Bibliographic Details
Main Authors: Akhona Vava, Juliano D. Paccez, Yihong Wang, Xuesong Gu, Manoj K. Bhasin, Michael Myers, Nelson C. Soares, Towia A. Libermann, Luiz F. Zerbini
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
prostate cancer
E3 ligase
DCUN1D1
neddylation
Wnt/β-catenin pathway
Online Access:https://www.mdpi.com/2073-4409/12/15/1973

Internet

https://www.mdpi.com/2073-4409/12/15/1973

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