DCUN1D1 Is an Essential Regulator of Prostate Cancer Proliferation and Tumour Growth That Acts through Neddylation of Cullin 1, 3, 4A and 5 and Deregulation of Wnt/Catenin Pathway
Defective in cullin neddylation 1 domain containing 1 (DCUN1D1) is an E3 ligase for the neddylation, a post-translational process similar to and occurring in parallel to ubiquitin proteasome pathway. Although established as an oncogene in a variety of squamous cell carcinomas, the precise role of DC...
Main Authors: | Akhona Vava, Juliano D. Paccez, Yihong Wang, Xuesong Gu, Manoj K. Bhasin, Michael Myers, Nelson C. Soares, Towia A. Libermann, Luiz F. Zerbini |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-07-01
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Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/12/15/1973 |
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