Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression

Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression

Summary: Metabolic heterogeneity within the tumor microenvironment promotes cancer cell growth and immune suppression. We determined the impact of mitochondria-targeted complex I inhibitors (Mito-CI) in melanoma. Mito-CI decreased mitochondria complex I oxygen consumption, Akt-FOXO signaling, blocke...

Full description

Bibliographic Details
Main Authors: Mahmoud AbuEid, Donna M. McAllister, Laura McOlash, Megan Cleland Harwig, Gang Cheng, Donovan Drouillard, Kathleen A. Boyle, Micael Hardy, Jacek Zielonka, Bryon D. Johnson, R. Blake Hill, Balaraman Kalyanaraman, Michael B. Dwinell
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:iScience
Subjects:
Components of the immune system
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221006210

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221006210

Similar Items