Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression

Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression

Summary: Metabolic heterogeneity within the tumor microenvironment promotes cancer cell growth and immune suppression. We determined the impact of mitochondria-targeted complex I inhibitors (Mito-CI) in melanoma. Mito-CI decreased mitochondria complex I oxygen consumption, Akt-FOXO signaling, blocke...

Full description

Bibliographic Details
Main Authors:	Mahmoud AbuEid, Donna M. McAllister, Laura McOlash, Megan Cleland Harwig, Gang Cheng, Donovan Drouillard, Kathleen A. Boyle, Micael Hardy, Jacek Zielonka, Bryon D. Johnson, R. Blake Hill, Balaraman Kalyanaraman, Michael B. Dwinell
Format:	Article
Language:	English
Published:	Elsevier 2021-06-01
Series:	iScience
Subjects:	Components of the immune system Cell biology Cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004221006210

Similar Items

Combining PEGylated mito-atovaquone with MCT and Krebs cycle redox inhibitors as a potential strategy to abrogate tumor cell proliferation
by: Gang Cheng, et al.
Published: (2022-03-01)

Corrigendum to 'A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds' [REDOX 14C (2017) 316–327]
by: Balaraman Kalyanaraman, et al.
Published: (2018-06-01)

A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds
by: Balaraman Kalyanaraman, et al.
Published: (2018-04-01)

Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies
by: Balaraman Kalyanaraman, et al.
Published: (2018-05-01)

Therapeutic Targeting of Tumor Cells and Tumor Immune Microenvironment Vulnerabilities
by: Balaraman Kalyanaraman, et al.
Published: (2022-06-01)

Green fluorescent proteins induce oxidative stress in cells: A worrisome new wrinkle in the application of the GFP reporter system to biological systems?
by: Balaraman Kalyanaraman, et al.
Published: (2017-08-01)

Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications
by: Balaraman Kalyanaraman, et al.
Published: (2024-05-01)

Antiproliferative effects of mitochondria-targeted N-acetylcysteine and analogs in cancer cells
by: Gang Cheng, et al.
Published: (2023-05-01)

Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models
by: Susan Tsai, et al.
Published: (2018-03-01)

Polyphenolic Boronates Inhibit Tumor Cell Proliferation: Potential Mitigators of Oxidants in the Tumor Microenvironment
by: Gang Cheng, et al.
Published: (2023-02-01)

2543 High concentrations of CXCL12 decrease pancreatic adenocarcinoma growth
by: Emily Vonderhaar, et al.
Published: (2018-06-01)

Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin
by: Mahmoud AbuEid, et al.
Published: (2022-12-01)

Adoptive cell therapy using PD-1+ myeloma-reactive T cells eliminates established myeloma in mice
by: Weiqing Jing, et al.
Published: (2017-06-01)

Synthesis of fluorinated triphenylphosphonium analogs that improve cancer cell selectivity and in vivo detection
by: Robert F. Keyes, et al.
Published: (2023-09-01)

STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models
by: Donna McAllister, et al.
Published: (2019-03-01)

Understanding Moral Disagreement: A Christian Perspectivalist Approach
by: Blake McAllister
Published: (2021-04-01)

Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria‐Targeted Atovaquone
by: Mofei Huang, et al.
Published: (2022-04-01)

Chemoprevention of Lung Cancer with a Combination of Mitochondria-Targeted Compounds
by: Qi Zhang, et al.
Published: (2022-05-01)

Mitochondria-targeted hydroxyurea inhibits OXPHOS and induces antiproliferative and immunomodulatory effects
by: Gang Cheng, et al.
Published: (2021-06-01)

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
by: Gang Cheng, et al.
Published: (2019-05-01)

The articulatory basis of positional asymmetries in phonological acquisition
by: McAllister, Tara Kathleen
Published: (2010)

NAC, NAC, Knockin’ on Heaven's door: Interpreting the mechanism of action of N-acetylcysteine in tumor and immune cells
by: Balaraman Kalyanaraman
Published: (2022-11-01)

Teaching the basics of the mechanism of doxorubicin-induced cardiotoxicity: Have we been barking up the wrong tree?
by: Balaraman Kalyanaraman
Published: (2020-01-01)

Do free radical NETwork and oxidative stress disparities in African Americans enhance their vulnerability to SARS-CoV-2 infection and COVID-19 severity?
by: Balaraman Kalyanaraman
Published: (2020-10-01)

Teaching the basics of repurposing mitochondria-targeted drugs: From Parkinson's disease to cancer and back to Parkinson's disease
by: Balaraman Kalyanaraman
Published: (2020-09-01)

Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms
by: Balaraman Kalyanaraman
Published: (2013-01-01)

Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism
by: Balaraman Kalyanaraman
Published: (2017-08-01)

Diapocynin and apocynin administration fails to significantly extend survival in G93A SOD1 ALS mice
by: Kari A. Trumbull, et al.
Published: (2012-01-01)

Mitochondria‐targeted atovaquone promotes anti‐lung cancer immunity by reshaping tumor microenvironment and enhancing energy metabolism of anti‐tumor immune cells
by: Donghai Xiong, et al.
Published: (2024-03-01)

Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon
by: Anindya Roy Chowdhury, et al.
Published: (2020-09-01)

Civil science policy in British industrial reconstruction, 1942-51
by: McAllister, J, et al.
Published: (1987)

Cancer-associated TERT promoter mutations abrogate telomerase silencing
by: Kunitoshi Chiba, et al.
Published: (2015-07-01)

Some studies on the ionic basis of the current-voltage relations in cardiac muscle
by: McAllister, R
Published: (1967)

The ice palace /
by: McAllister, Angela
Published: (1994)

Electric cables handbook /
by: McAllister, D.
Published: (1982)

A process-driven platform to manage datasets for research
by: Gordon McAllister
Published: (2017-04-01)

Retrospection, Regret, and Contingency in Dickens’s Late Midlives
by: David McAllister
Published: (2021-01-01)

Quotes, Paraphrases, and Allusions: Text Reuse in Sanskrit Commentaries and How to Encode It
by: Patrick McAllister
Published: (2021-04-01)

Socio-spatial practices of well-being: authors of civic ecologies
by: McAllister, Jane
Published: (2023)

History and the Popular: Rewriting National Origins at the Argentine Bicentenary
by: Catriona McAllister
Published: (2016-04-01)