Lipid Peroxidation in Obesity: Can Bariatric Surgery Help?
Obesity and chronic oxidative stress, often being associated with each other in a vicious circle, are important factors of chronic diseases. Although it was usually considered to accompany aging and wealth, global trends show the increase in obesity among children even in Third World countries. Bein...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/8/1537 |
| _version_ | 1797432540184707072 |
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| author | Ana Maria Soldo Ivo Soldo Andrija Karačić Marcela Konjevod Matea Nikolac Perkovic Tanja Matijevic Glavan Martina Luksic Neven Žarković Morana Jaganjac |
| author_facet | Ana Maria Soldo Ivo Soldo Andrija Karačić Marcela Konjevod Matea Nikolac Perkovic Tanja Matijevic Glavan Martina Luksic Neven Žarković Morana Jaganjac |
| author_sort | Ana Maria Soldo |
| collection | DOAJ |
| description | Obesity and chronic oxidative stress, often being associated with each other in a vicious circle, are important factors of chronic diseases. Although it was usually considered to accompany aging and wealth, global trends show the increase in obesity among children even in Third World countries. Being manifested by an imbalance between energy consumption and food intake, obesity is characterized by an excessive or abnormal fat accumulation, impaired redox homeostasis and metabolic changes often associated with the self-catalyzed lipid peroxidation generating 4-hydroxynonenal, pluripotent bioactive peroxidation product of polyunsaturated fatty acids. Conservative methods targeting obesity produced only modest and transient results in the treatment of morbid obesity. Therefore, in recent years, surgery, primarily bariatric, became an attractive treatment for morbid obesity. Since adipose tissue is well known as a stress organ with pronounced endocrine functions, surgery results in redox balance and metabolic improvement of the entire organism. The source of bioactive lipids and lipid-soluble antioxidants, and the complex pathophysiology of lipid peroxidation should thus be considered from the aspects of personalized and integrative biomedicine to treat obesity in an appropriate way. |
| first_indexed | 2024-03-09T10:02:17Z |
| format | Article |
| id | doaj.art-3632f4fe2e034469a409508c38629588 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T10:02:17Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-3632f4fe2e034469a409508c386295882023-12-01T23:20:11ZengMDPI AGAntioxidants2076-39212022-08-01118153710.3390/antiox11081537Lipid Peroxidation in Obesity: Can Bariatric Surgery Help?Ana Maria Soldo0Ivo Soldo1Andrija Karačić2Marcela Konjevod3Matea Nikolac Perkovic4Tanja Matijevic Glavan5Martina Luksic6Neven Žarković7Morana Jaganjac8Department of Gastroenterology, General Hospital “Dr. Ivo Pedisic”, 44000 Sisak, CroatiaSurgery Clinic, University Hospital Sveti Duh, 10000 Zagreb, CroatiaSurgery Clinic, University Hospital Sveti Duh, 10000 Zagreb, CroatiaDivision of Molecular Medicine, Ruder Boskovic Institute, 10000 Zagreb, CroatiaDivision of Molecular Medicine, Ruder Boskovic Institute, 10000 Zagreb, CroatiaDivision of Molecular Medicine, Ruder Boskovic Institute, 10000 Zagreb, CroatiaDepartment of Endocrinology, Diabetes and Metabolic Diseases, University Hospital Sveti Duh, 10000 Zagreb, CroatiaDivision of Molecular Medicine, Ruder Boskovic Institute, 10000 Zagreb, CroatiaDivision of Molecular Medicine, Ruder Boskovic Institute, 10000 Zagreb, CroatiaObesity and chronic oxidative stress, often being associated with each other in a vicious circle, are important factors of chronic diseases. Although it was usually considered to accompany aging and wealth, global trends show the increase in obesity among children even in Third World countries. Being manifested by an imbalance between energy consumption and food intake, obesity is characterized by an excessive or abnormal fat accumulation, impaired redox homeostasis and metabolic changes often associated with the self-catalyzed lipid peroxidation generating 4-hydroxynonenal, pluripotent bioactive peroxidation product of polyunsaturated fatty acids. Conservative methods targeting obesity produced only modest and transient results in the treatment of morbid obesity. Therefore, in recent years, surgery, primarily bariatric, became an attractive treatment for morbid obesity. Since adipose tissue is well known as a stress organ with pronounced endocrine functions, surgery results in redox balance and metabolic improvement of the entire organism. The source of bioactive lipids and lipid-soluble antioxidants, and the complex pathophysiology of lipid peroxidation should thus be considered from the aspects of personalized and integrative biomedicine to treat obesity in an appropriate way.https://www.mdpi.com/2076-3921/11/8/1537obesityadipose tissue dysfunctionredox homeostasislipid peroxidation4-hydroxynonenalbariatric surgery |
| spellingShingle | Ana Maria Soldo Ivo Soldo Andrija Karačić Marcela Konjevod Matea Nikolac Perkovic Tanja Matijevic Glavan Martina Luksic Neven Žarković Morana Jaganjac Lipid Peroxidation in Obesity: Can Bariatric Surgery Help? Antioxidants obesity adipose tissue dysfunction redox homeostasis lipid peroxidation 4-hydroxynonenal bariatric surgery |
| title | Lipid Peroxidation in Obesity: Can Bariatric Surgery Help? |
| title_full | Lipid Peroxidation in Obesity: Can Bariatric Surgery Help? |
| title_fullStr | Lipid Peroxidation in Obesity: Can Bariatric Surgery Help? |
| title_full_unstemmed | Lipid Peroxidation in Obesity: Can Bariatric Surgery Help? |
| title_short | Lipid Peroxidation in Obesity: Can Bariatric Surgery Help? |
| title_sort | lipid peroxidation in obesity can bariatric surgery help |
| topic | obesity adipose tissue dysfunction redox homeostasis lipid peroxidation 4-hydroxynonenal bariatric surgery |
| url | https://www.mdpi.com/2076-3921/11/8/1537 |
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