EARLY DIAGNOSTICS AND TOTAL GASTRECTOMY OF HEREDITARY DIFFUSE GASTRIC CANCER
The case report describes a rare case of hereditary diffuse gastric cancer, associated with a CDH1 gene mutation and reported in the Russian population for the fist time. In february 2013, after a medical genetic counseling in the laboratory of clinical oncogenetics of the Institute of Clinical Onco...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2017-12-01
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| Series: | Успехи молекулярной онкологии |
| Subjects: | |
| Online Access: | https://umo.abvpress.ru/jour/article/view/116 |
| _version_ | 1826559139877224448 |
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| author | L. N. Lyubchenko M. G. Filippova O. A. Anurova P. B. Nazliev I. S. Stilidi M. M. Davydov |
| author_facet | L. N. Lyubchenko M. G. Filippova O. A. Anurova P. B. Nazliev I. S. Stilidi M. M. Davydov |
| author_sort | L. N. Lyubchenko |
| collection | DOAJ |
| description | The case report describes a rare case of hereditary diffuse gastric cancer, associated with a CDH1 gene mutation and reported in the Russian population for the fist time. In february 2013, after a medical genetic counseling in the laboratory of clinical oncogenetics of the Institute of Clinical Oncology of the N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia the 28 years old patient was applied to due to a family history of gastric cancer. Based on the results of the molecular genetic study, thе mutation in the CDH1 gene was found, which determines the risk of diffuse gastric cancer during life beyond 80 %. Histological examination of the material of the gastric mucosa biopsy performed during the esophagogastroduodenoscopy revealed single foci of the ring-cell cancer in the intrinsic plate of the gastric mucosa. In the department of abdominal oncology, the Research Institute of Clinical Oncology of the N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia a splash-preserving gastrectomy for Roux was performed with the formation of a small intestine tank, lymphodissection D2. |
| first_indexed | 2024-03-12T18:43:34Z |
| format | Article |
| id | doaj.art-363695c0d5df46e69786f6cbf37b5b0c |
| institution | Directory Open Access Journal |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| last_indexed | 2025-03-14T08:55:39Z |
| publishDate | 2017-12-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj.art-363695c0d5df46e69786f6cbf37b5b0c2025-03-02T12:45:05ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872017-12-0144323610.17650/2313-805X-2017-4-4-32-36109EARLY DIAGNOSTICS AND TOTAL GASTRECTOMY OF HEREDITARY DIFFUSE GASTRIC CANCERL. N. Lyubchenko0M. G. Filippova1O. A. Anurova2P. B. Nazliev3I. S. Stilidi4M. M. Davydov5N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaThe case report describes a rare case of hereditary diffuse gastric cancer, associated with a CDH1 gene mutation and reported in the Russian population for the fist time. In february 2013, after a medical genetic counseling in the laboratory of clinical oncogenetics of the Institute of Clinical Oncology of the N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia the 28 years old patient was applied to due to a family history of gastric cancer. Based on the results of the molecular genetic study, thе mutation in the CDH1 gene was found, which determines the risk of diffuse gastric cancer during life beyond 80 %. Histological examination of the material of the gastric mucosa biopsy performed during the esophagogastroduodenoscopy revealed single foci of the ring-cell cancer in the intrinsic plate of the gastric mucosa. In the department of abdominal oncology, the Research Institute of Clinical Oncology of the N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia a splash-preserving gastrectomy for Roux was performed with the formation of a small intestine tank, lymphodissection D2.https://umo.abvpress.ru/jour/article/view/116hereditary diffuse gastric cancercdh1 genegastrectomymolecular-genetic analysis |
| spellingShingle | L. N. Lyubchenko M. G. Filippova O. A. Anurova P. B. Nazliev I. S. Stilidi M. M. Davydov EARLY DIAGNOSTICS AND TOTAL GASTRECTOMY OF HEREDITARY DIFFUSE GASTRIC CANCER Успехи молекулярной онкологии hereditary diffuse gastric cancer cdh1 gene gastrectomy molecular-genetic analysis |
| title | EARLY DIAGNOSTICS AND TOTAL GASTRECTOMY OF HEREDITARY DIFFUSE GASTRIC CANCER |
| title_full | EARLY DIAGNOSTICS AND TOTAL GASTRECTOMY OF HEREDITARY DIFFUSE GASTRIC CANCER |
| title_fullStr | EARLY DIAGNOSTICS AND TOTAL GASTRECTOMY OF HEREDITARY DIFFUSE GASTRIC CANCER |
| title_full_unstemmed | EARLY DIAGNOSTICS AND TOTAL GASTRECTOMY OF HEREDITARY DIFFUSE GASTRIC CANCER |
| title_short | EARLY DIAGNOSTICS AND TOTAL GASTRECTOMY OF HEREDITARY DIFFUSE GASTRIC CANCER |
| title_sort | early diagnostics and total gastrectomy of hereditary diffuse gastric cancer |
| topic | hereditary diffuse gastric cancer cdh1 gene gastrectomy molecular-genetic analysis |
| url | https://umo.abvpress.ru/jour/article/view/116 |
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