The Anticonvulsant and Antioxidant Effects of Berberine in Kainate-induced Temporal Lobe Epilepsy in Rats
Introduction: Temporal lobe epilepsy(TLE) is a long lasting neurological disorder in which patients suffer from spontaneous seizures. New treatments with novel mechanisms of action are needed to help those patients whose seizures are resistant to available drugs. In this study, we investigated the p...
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2014-05-01
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| Series: | Basic and Clinical Neuroscience |
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| Online Access: | http://bcn.iums.ac.ir/browse.php?a_code=A-10-88-3&slc_lang=en&sid=1 |
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| author | Tourandokht Baluchnejadmojarad Mehrdad Roghani |
| author_facet | Tourandokht Baluchnejadmojarad Mehrdad Roghani |
| author_sort | Tourandokht Baluchnejadmojarad |
| collection | DOAJ |
| description | Introduction: Temporal lobe epilepsy(TLE) is a long lasting neurological disorder in which patients suffer from spontaneous seizures. New treatments with novel mechanisms of action are needed to help those patients whose seizures are resistant to available drugs. In this study, we investigated the possible neuroprotective effect of berberine in an intrahippocampal kainate model of TLE in rat. Methods: In the present study, the anticonvulsant and antioxidant effects of intraperitoneal administration of berberine(25, 50 and 100 mg/kg), was evaluated in intrahippocampal kainate(4g)-induced TLE in rats. Results: The results showed that the kainate rats exhibit acute and spontaneous seizures in 24 hours and two weeks after intrahippocampal kainic acid injection. Administration of berberine, significantly decreased Racine score and rate of incidence of seizure in kainate rats(P<0.05). On the other hand, berberine ameliorated the lipid peroxidation(P<0.001) and nitrite(P<0.001) level, but had no effect on SOD activity. Discussion: These data suggest that berberine pretreatment could attenuate spontaneous recurrent seizures. Since, administration of berberine decreased lipid peroxidation in kainate rats, it seems that berberine,s favourable effect is due to its effectiveness in lessening of oxidative stress in rat. Key words: Kainic acid, Berberine, Seizure, Hippocampus, Oxidative stress, Rat |
| first_indexed | 2024-03-07T16:40:13Z |
| format | Article |
| id | doaj.art-3637609bbb37498ebe37a3ca6e61337e |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T16:40:13Z |
| publishDate | 2014-05-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-3637609bbb37498ebe37a3ca6e61337e2024-03-03T08:32:15ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422014-05-0152124130The Anticonvulsant and Antioxidant Effects of Berberine in Kainate-induced Temporal Lobe Epilepsy in RatsTourandokht Baluchnejadmojarad0Mehrdad Roghani1 Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Neurophysiology Research Center, Shahed University, Tehran, Iran. Introduction: Temporal lobe epilepsy(TLE) is a long lasting neurological disorder in which patients suffer from spontaneous seizures. New treatments with novel mechanisms of action are needed to help those patients whose seizures are resistant to available drugs. In this study, we investigated the possible neuroprotective effect of berberine in an intrahippocampal kainate model of TLE in rat. Methods: In the present study, the anticonvulsant and antioxidant effects of intraperitoneal administration of berberine(25, 50 and 100 mg/kg), was evaluated in intrahippocampal kainate(4g)-induced TLE in rats. Results: The results showed that the kainate rats exhibit acute and spontaneous seizures in 24 hours and two weeks after intrahippocampal kainic acid injection. Administration of berberine, significantly decreased Racine score and rate of incidence of seizure in kainate rats(P<0.05). On the other hand, berberine ameliorated the lipid peroxidation(P<0.001) and nitrite(P<0.001) level, but had no effect on SOD activity. Discussion: These data suggest that berberine pretreatment could attenuate spontaneous recurrent seizures. Since, administration of berberine decreased lipid peroxidation in kainate rats, it seems that berberine,s favourable effect is due to its effectiveness in lessening of oxidative stress in rat. Key words: Kainic acid, Berberine, Seizure, Hippocampus, Oxidative stress, Rathttp://bcn.iums.ac.ir/browse.php?a_code=A-10-88-3&slc_lang=en&sid=1Kainic Acid Berberine Seizure Hippocampus Oxidative Stress Rat |
| spellingShingle | Tourandokht Baluchnejadmojarad Mehrdad Roghani The Anticonvulsant and Antioxidant Effects of Berberine in Kainate-induced Temporal Lobe Epilepsy in Rats Basic and Clinical Neuroscience Kainic Acid Berberine Seizure Hippocampus Oxidative Stress Rat |
| title | The Anticonvulsant and Antioxidant Effects of Berberine in Kainate-induced Temporal Lobe Epilepsy in Rats |
| title_full | The Anticonvulsant and Antioxidant Effects of Berberine in Kainate-induced Temporal Lobe Epilepsy in Rats |
| title_fullStr | The Anticonvulsant and Antioxidant Effects of Berberine in Kainate-induced Temporal Lobe Epilepsy in Rats |
| title_full_unstemmed | The Anticonvulsant and Antioxidant Effects of Berberine in Kainate-induced Temporal Lobe Epilepsy in Rats |
| title_short | The Anticonvulsant and Antioxidant Effects of Berberine in Kainate-induced Temporal Lobe Epilepsy in Rats |
| title_sort | anticonvulsant and antioxidant effects of berberine in kainate induced temporal lobe epilepsy in rats |
| topic | Kainic Acid Berberine Seizure Hippocampus Oxidative Stress Rat |
| url | http://bcn.iums.ac.ir/browse.php?a_code=A-10-88-3&slc_lang=en&sid=1 |
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