Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase
Dysfunction of enteropeptidase (EP) can result in pancreatitis, a life-threatening disease. Yang et al. report a series of EP structures representing the EP catalytic cycle and propose a mechanistic model of enzyme function.
Bibliographic Details
| Main Authors: |
Xiaoli Yang,
Zhanyu Ding,
Lisi Peng,
Qiuyue Song,
Deyu Zhang,
Fang Cui,
Chuanchao Xia,
Keliang Li,
Hua Yin,
Shiyu Li,
Zhaoshen Li,
Haojie Huang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-34364-9
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