Catalytic Approaches to Multicomponent Reactions: A Critical Review and Perspectives on the Roles of Catalysis
In this review, we comprehensively describe catalyzed multicomponent reactions (MCRs) and the multiple roles of catalysis combined with key parameters to perform these transformations. Besides improving yields and shortening reaction times, catalysis is vital to achieving greener protocols and to fu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/1/132 |
| _version_ | 1827668120271060992 |
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| author | Brenno A. D. Neto Rafael O. Rocha Marcelo O. Rodrigues |
| author_facet | Brenno A. D. Neto Rafael O. Rocha Marcelo O. Rodrigues |
| author_sort | Brenno A. D. Neto |
| collection | DOAJ |
| description | In this review, we comprehensively describe catalyzed multicomponent reactions (MCRs) and the multiple roles of catalysis combined with key parameters to perform these transformations. Besides improving yields and shortening reaction times, catalysis is vital to achieving greener protocols and to furthering the MCR field of research. Considering that MCRs typically have two or more possible reaction pathways to explain the transformation, catalysis is essential for selecting a reaction route and avoiding byproduct formation. Key parameters, such as temperature, catalyst amounts and reagent quantities, were analyzed. Solvent effects, which are likely the most neglected topic in MCRs, as well as their combined roles with catalysis, are critically discussed. Stereocontrolled MCRs, rarely observed without the presence of a catalytic system, are also presented and discussed in this review. Perspectives on the use of catalytic systems for improved and greener MCRs are finally presented. |
| first_indexed | 2024-03-10T03:30:40Z |
| format | Article |
| id | doaj.art-363a21fadc71494d8d1d7da2b26631e8 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:30:40Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-363a21fadc71494d8d1d7da2b26631e82023-11-23T11:57:10ZengMDPI AGMolecules1420-30492021-12-0127113210.3390/molecules27010132Catalytic Approaches to Multicomponent Reactions: A Critical Review and Perspectives on the Roles of CatalysisBrenno A. D. Neto0Rafael O. Rocha1Marcelo O. Rodrigues2Laboratory of Medicinal and Technological Chemistry, University of Brasília, Chemistry Institute (IQ-UnB), Campus Universitário Darcy Ribeiro, Brasilia 70910-900, BrazilLaboratory of Medicinal and Technological Chemistry, University of Brasília, Chemistry Institute (IQ-UnB), Campus Universitário Darcy Ribeiro, Brasilia 70910-900, BrazilLaboratory of Medicinal and Technological Chemistry, University of Brasília, Chemistry Institute (IQ-UnB), Campus Universitário Darcy Ribeiro, Brasilia 70910-900, BrazilIn this review, we comprehensively describe catalyzed multicomponent reactions (MCRs) and the multiple roles of catalysis combined with key parameters to perform these transformations. Besides improving yields and shortening reaction times, catalysis is vital to achieving greener protocols and to furthering the MCR field of research. Considering that MCRs typically have two or more possible reaction pathways to explain the transformation, catalysis is essential for selecting a reaction route and avoiding byproduct formation. Key parameters, such as temperature, catalyst amounts and reagent quantities, were analyzed. Solvent effects, which are likely the most neglected topic in MCRs, as well as their combined roles with catalysis, are critically discussed. Stereocontrolled MCRs, rarely observed without the presence of a catalytic system, are also presented and discussed in this review. Perspectives on the use of catalytic systems for improved and greener MCRs are finally presented.https://www.mdpi.com/1420-3049/27/1/132catalysismulticomponent reactionsmechanismssolvent effectsstereocontrol |
| spellingShingle | Brenno A. D. Neto Rafael O. Rocha Marcelo O. Rodrigues Catalytic Approaches to Multicomponent Reactions: A Critical Review and Perspectives on the Roles of Catalysis Molecules catalysis multicomponent reactions mechanisms solvent effects stereocontrol |
| title | Catalytic Approaches to Multicomponent Reactions: A Critical Review and Perspectives on the Roles of Catalysis |
| title_full | Catalytic Approaches to Multicomponent Reactions: A Critical Review and Perspectives on the Roles of Catalysis |
| title_fullStr | Catalytic Approaches to Multicomponent Reactions: A Critical Review and Perspectives on the Roles of Catalysis |
| title_full_unstemmed | Catalytic Approaches to Multicomponent Reactions: A Critical Review and Perspectives on the Roles of Catalysis |
| title_short | Catalytic Approaches to Multicomponent Reactions: A Critical Review and Perspectives on the Roles of Catalysis |
| title_sort | catalytic approaches to multicomponent reactions a critical review and perspectives on the roles of catalysis |
| topic | catalysis multicomponent reactions mechanisms solvent effects stereocontrol |
| url | https://www.mdpi.com/1420-3049/27/1/132 |
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