Investigation of The Efficacy of Lymph Node Core Needle Biopsy in the Diagnosis of the cause of Lymphadenopathy
Background and Aim: Core needle biopsy (CNB) is less invasive and has fewer side effects compared to surgical procedures, and provides accurate information about the nature of the tumor. The aim of this study was to evaluate the efficacy of CNB in the diagnosis of the cause of lymphadenopathy. Mater...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Kurdistan University of Medical Sciences
2023-10-01
|
| Series: | مجله علمی دانشگاه علوم پزشکی کردستان |
| Subjects: | |
| Online Access: | http://sjku.muk.ac.ir/article-1-7150-en.pdf |
| _version_ | 1797285588722778112 |
|---|---|
| author | Melika Oladzad Nasser Ghaemian Hemmatollah Gholinia Ahangar Sahar Sadr Moharrerpour Housein Ghorbani |
| author_facet | Melika Oladzad Nasser Ghaemian Hemmatollah Gholinia Ahangar Sahar Sadr Moharrerpour Housein Ghorbani |
| author_sort | Melika Oladzad |
| collection | DOAJ |
| description | Background and Aim: Core needle biopsy (CNB) is less invasive and has fewer side effects compared to surgical procedures, and provides accurate information about the nature of the tumor. The aim of this study was to evaluate the efficacy of CNB in the diagnosis of the cause of lymphadenopathy.
Materials and Methods: In this study, 153 patients with lymphadenopathy underwent CNB from 2014 to 2018. Immunohistochemistry staining with appropriate markers was performed. Excisional biopsy, clinical and radiological data were evaluated using spss-21 softwere, data were analyzed by one way ANOVA and tukey test (p<0/05).
Results: Diffuse large B-cell lymphoma was more frequent (41%). Histopathological diagnosis of core needle biopsy was correct in 83.23% of the patients,among them 11.11% were confirmed by excisional biopsy and 88.88% by clinical and radiological findings. There was a significant relationship between the mean age of the patients and location of lymphadenopathy (P = 0.02) and also between the mean age and pathology diagnosis (P<0.001). The accuracy, sensitivity, and positive predictive value of CNB were 90%, 100%, and 90%, respectively.
Conclusion: Diagnosis of the cause of lymphadenopathy by CNB was correct in most cases and its diagnostic efficacy was confirmed. The present results recommend CNB as a suitable method without side effects for investigation of the cause of lymphadenopathy. |
| first_indexed | 2024-03-07T18:05:21Z |
| format | Article |
| id | doaj.art-363c341295124652b7dcc2d482a471de |
| institution | Directory Open Access Journal |
| issn | 1560-652X 2345-4040 |
| language | fas |
| last_indexed | 2024-03-07T18:05:21Z |
| publishDate | 2023-10-01 |
| publisher | Kurdistan University of Medical Sciences |
| record_format | Article |
| series | مجله علمی دانشگاه علوم پزشکی کردستان |
| spelling | doaj.art-363c341295124652b7dcc2d482a471de2024-03-02T09:28:13ZfasKurdistan University of Medical Sciencesمجله علمی دانشگاه علوم پزشکی کردستان1560-652X2345-40402023-10-012847794Investigation of The Efficacy of Lymph Node Core Needle Biopsy in the Diagnosis of the cause of LymphadenopathyMelika Oladzad0Nasser Ghaemian1Hemmatollah Gholinia Ahangar2Sahar Sadr Moharrerpour3Housein Ghorbani4 Student Reseach Comitee, Babol University of Medical Sciences, Babol, Iran Department of of Radiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Assistant Professor of Pediatric Nephrology, Non-Communicable Pediatric Disease Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Background and Aim: Core needle biopsy (CNB) is less invasive and has fewer side effects compared to surgical procedures, and provides accurate information about the nature of the tumor. The aim of this study was to evaluate the efficacy of CNB in the diagnosis of the cause of lymphadenopathy. Materials and Methods: In this study, 153 patients with lymphadenopathy underwent CNB from 2014 to 2018. Immunohistochemistry staining with appropriate markers was performed. Excisional biopsy, clinical and radiological data were evaluated using spss-21 softwere, data were analyzed by one way ANOVA and tukey test (p<0/05). Results: Diffuse large B-cell lymphoma was more frequent (41%). Histopathological diagnosis of core needle biopsy was correct in 83.23% of the patients,among them 11.11% were confirmed by excisional biopsy and 88.88% by clinical and radiological findings. There was a significant relationship between the mean age of the patients and location of lymphadenopathy (P = 0.02) and also between the mean age and pathology diagnosis (P<0.001). The accuracy, sensitivity, and positive predictive value of CNB were 90%, 100%, and 90%, respectively. Conclusion: Diagnosis of the cause of lymphadenopathy by CNB was correct in most cases and its diagnostic efficacy was confirmed. The present results recommend CNB as a suitable method without side effects for investigation of the cause of lymphadenopathy.http://sjku.muk.ac.ir/article-1-7150-en.pdflymph nodecore needle biopsylymphadenopathy |
| spellingShingle | Melika Oladzad Nasser Ghaemian Hemmatollah Gholinia Ahangar Sahar Sadr Moharrerpour Housein Ghorbani Investigation of The Efficacy of Lymph Node Core Needle Biopsy in the Diagnosis of the cause of Lymphadenopathy مجله علمی دانشگاه علوم پزشکی کردستان lymph node core needle biopsy lymphadenopathy |
| title | Investigation of The Efficacy of Lymph Node Core Needle Biopsy in the Diagnosis of the cause of Lymphadenopathy |
| title_full | Investigation of The Efficacy of Lymph Node Core Needle Biopsy in the Diagnosis of the cause of Lymphadenopathy |
| title_fullStr | Investigation of The Efficacy of Lymph Node Core Needle Biopsy in the Diagnosis of the cause of Lymphadenopathy |
| title_full_unstemmed | Investigation of The Efficacy of Lymph Node Core Needle Biopsy in the Diagnosis of the cause of Lymphadenopathy |
| title_short | Investigation of The Efficacy of Lymph Node Core Needle Biopsy in the Diagnosis of the cause of Lymphadenopathy |
| title_sort | investigation of the efficacy of lymph node core needle biopsy in the diagnosis of the cause of lymphadenopathy |
| topic | lymph node core needle biopsy lymphadenopathy |
| url | http://sjku.muk.ac.ir/article-1-7150-en.pdf |
| work_keys_str_mv | AT melikaoladzad investigationoftheefficacyoflymphnodecoreneedlebiopsyinthediagnosisofthecauseoflymphadenopathy AT nasserghaemian investigationoftheefficacyoflymphnodecoreneedlebiopsyinthediagnosisofthecauseoflymphadenopathy AT hemmatollahgholiniaahangar investigationoftheefficacyoflymphnodecoreneedlebiopsyinthediagnosisofthecauseoflymphadenopathy AT saharsadrmoharrerpour investigationoftheefficacyoflymphnodecoreneedlebiopsyinthediagnosisofthecauseoflymphadenopathy AT houseinghorbani investigationoftheefficacyoflymphnodecoreneedlebiopsyinthediagnosisofthecauseoflymphadenopathy |