Dexamethasone Conjugates: Synthetic Approaches and Medical Prospects
Dexamethasone (DEX) is the most commonly prescribed glucocorticoid (GC) and has a wide spectrum of pharmacological activity. However, steroid drugs like DEX can have severe side effects on non-target organs. One strategy to reduce these side effects is to develop targeted systems with the controlled...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/4/341 |
| _version_ | 1797539737942097920 |
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| author | Natallia V. Dubashynskaya Anton N. Bokatyi Yury A. Skorik |
| author_facet | Natallia V. Dubashynskaya Anton N. Bokatyi Yury A. Skorik |
| author_sort | Natallia V. Dubashynskaya |
| collection | DOAJ |
| description | Dexamethasone (DEX) is the most commonly prescribed glucocorticoid (GC) and has a wide spectrum of pharmacological activity. However, steroid drugs like DEX can have severe side effects on non-target organs. One strategy to reduce these side effects is to develop targeted systems with the controlled release by conjugation to polymeric carriers. This review describes the methods available for the synthesis of DEX conjugates (carbodiimide chemistry, solid-phase synthesis, reversible addition fragmentation-chain transfer [RAFT] polymerization, click reactions, and 2-iminothiolane chemistry) and perspectives for their medical application as GC drug or gene delivery systems for anti-tumor therapy. Additionally, the review focuses on the development of DEX conjugates with different physical-chemical properties as successful delivery systems in the target organs such as eye, joint, kidney, and others. Finally, polymer conjugates with improved transfection activity in which DEX is used as a vector for gene delivery in the cell nucleus have been described. |
| first_indexed | 2024-03-10T12:50:06Z |
| format | Article |
| id | doaj.art-363cb3ec8a17470191b64164991f34d1 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T12:50:06Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-363cb3ec8a17470191b64164991f34d12023-11-21T13:06:52ZengMDPI AGBiomedicines2227-90592021-03-019434110.3390/biomedicines9040341Dexamethasone Conjugates: Synthetic Approaches and Medical ProspectsNatallia V. Dubashynskaya0Anton N. Bokatyi1Yury A. Skorik2Institute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoy pr. V.O. 31, 199004 St. Petersburg, RussiaInstitute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoy pr. V.O. 31, 199004 St. Petersburg, RussiaInstitute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoy pr. V.O. 31, 199004 St. Petersburg, RussiaDexamethasone (DEX) is the most commonly prescribed glucocorticoid (GC) and has a wide spectrum of pharmacological activity. However, steroid drugs like DEX can have severe side effects on non-target organs. One strategy to reduce these side effects is to develop targeted systems with the controlled release by conjugation to polymeric carriers. This review describes the methods available for the synthesis of DEX conjugates (carbodiimide chemistry, solid-phase synthesis, reversible addition fragmentation-chain transfer [RAFT] polymerization, click reactions, and 2-iminothiolane chemistry) and perspectives for their medical application as GC drug or gene delivery systems for anti-tumor therapy. Additionally, the review focuses on the development of DEX conjugates with different physical-chemical properties as successful delivery systems in the target organs such as eye, joint, kidney, and others. Finally, polymer conjugates with improved transfection activity in which DEX is used as a vector for gene delivery in the cell nucleus have been described.https://www.mdpi.com/2227-9059/9/4/341dexamethasonedrug conjugatedrug delivery systemgene delivery systembiopolymers |
| spellingShingle | Natallia V. Dubashynskaya Anton N. Bokatyi Yury A. Skorik Dexamethasone Conjugates: Synthetic Approaches and Medical Prospects Biomedicines dexamethasone drug conjugate drug delivery system gene delivery system biopolymers |
| title | Dexamethasone Conjugates: Synthetic Approaches and Medical Prospects |
| title_full | Dexamethasone Conjugates: Synthetic Approaches and Medical Prospects |
| title_fullStr | Dexamethasone Conjugates: Synthetic Approaches and Medical Prospects |
| title_full_unstemmed | Dexamethasone Conjugates: Synthetic Approaches and Medical Prospects |
| title_short | Dexamethasone Conjugates: Synthetic Approaches and Medical Prospects |
| title_sort | dexamethasone conjugates synthetic approaches and medical prospects |
| topic | dexamethasone drug conjugate drug delivery system gene delivery system biopolymers |
| url | https://www.mdpi.com/2227-9059/9/4/341 |
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