Efficacy and safety of berberine for premature ventricular contractions: a meta-analysis and systematic review of randomized controlled trials
AbstractContext Berberine is a potential drug that can effectively treat cardiovascular diseases, including premature ventricular contractions (PVCs).Objective This study was conducted to assess the efficacy and safety of berberine for PVCs.Methods The literature was searched using PubMed, Cochrane...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Pharmaceutical Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13880209.2023.2248167 |
| _version_ | 1797234821478481920 |
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| author | Meng Qiao Chao Lei Chaoren Tan Cuncun Lu Zijia Chen Qiang Zhang Zhifei Wang |
| author_facet | Meng Qiao Chao Lei Chaoren Tan Cuncun Lu Zijia Chen Qiang Zhang Zhifei Wang |
| author_sort | Meng Qiao |
| collection | DOAJ |
| description | AbstractContext Berberine is a potential drug that can effectively treat cardiovascular diseases, including premature ventricular contractions (PVCs).Objective This study was conducted to assess the efficacy and safety of berberine for PVCs.Methods The literature was searched using PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang, and Chinese Biomedical Literature Database (CBM) for randomized controlled trials (RCTs) from inception to October 1, 2022. The risk of bias was assessed using the Revised Cochrane risk-of-bias tool for randomized trials, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was adopted to assess the quality of evidence.Results Ten RCTs with 896 participants were included in the meta-analysis. The results showed that compared to antiarrhythmic drugs (AD), berberine (BE) combined with AD had a higher effective rate (RR = 1.26; 95% CI:1.12, 1.42; p = 0.0001) with no significant incidence of adverse reactions (RR = 0.93; 95% CI:0.33, 2.57; p = 0.88), and BE alone had no significant difference in effective rate (RR = 0.91; 95% CI:0.77, 1.07; p = 0.23), and a lower incidence of adverse reactions (RR = 0.38; 95% CI:0.15, 0.97; p = 0.04) and recurrence rate (RR = 0.40; 95% CI:0.18, 0.88; p = 0.02).Conclusions The results suggest that BE is an effective and safe adjunctive method for PVCs. In addition, BE is recommended for patients with PVCs who had severe adverse reactions after administrating AD as an alternative therapy. |
| first_indexed | 2024-03-09T00:08:56Z |
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| id | doaj.art-363eed86ce984557a9228f66f543aecf |
| institution | Directory Open Access Journal |
| issn | 1388-0209 1744-5116 |
| language | English |
| last_indexed | 2024-04-24T16:38:09Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Pharmaceutical Biology |
| spelling | doaj.art-363eed86ce984557a9228f66f543aecf2024-03-29T11:10:26ZengTaylor & Francis GroupPharmaceutical Biology1388-02091744-51162023-12-016111474148310.1080/13880209.2023.2248167Efficacy and safety of berberine for premature ventricular contractions: a meta-analysis and systematic review of randomized controlled trialsMeng Qiao0Chao Lei1Chaoren Tan2Cuncun Lu3Zijia Chen4Qiang Zhang5Zhifei Wang6Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, PR ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, PR ChinaInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Science, Beijing, PR ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, PR ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, PR ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, PR ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, PR ChinaAbstractContext Berberine is a potential drug that can effectively treat cardiovascular diseases, including premature ventricular contractions (PVCs).Objective This study was conducted to assess the efficacy and safety of berberine for PVCs.Methods The literature was searched using PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang, and Chinese Biomedical Literature Database (CBM) for randomized controlled trials (RCTs) from inception to October 1, 2022. The risk of bias was assessed using the Revised Cochrane risk-of-bias tool for randomized trials, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was adopted to assess the quality of evidence.Results Ten RCTs with 896 participants were included in the meta-analysis. The results showed that compared to antiarrhythmic drugs (AD), berberine (BE) combined with AD had a higher effective rate (RR = 1.26; 95% CI:1.12, 1.42; p = 0.0001) with no significant incidence of adverse reactions (RR = 0.93; 95% CI:0.33, 2.57; p = 0.88), and BE alone had no significant difference in effective rate (RR = 0.91; 95% CI:0.77, 1.07; p = 0.23), and a lower incidence of adverse reactions (RR = 0.38; 95% CI:0.15, 0.97; p = 0.04) and recurrence rate (RR = 0.40; 95% CI:0.18, 0.88; p = 0.02).Conclusions The results suggest that BE is an effective and safe adjunctive method for PVCs. In addition, BE is recommended for patients with PVCs who had severe adverse reactions after administrating AD as an alternative therapy.https://www.tandfonline.com/doi/10.1080/13880209.2023.2248167Coptis chinensistraditional Chinese medicinecomplementary alternative medicineantiarrhythmic drugs |
| spellingShingle | Meng Qiao Chao Lei Chaoren Tan Cuncun Lu Zijia Chen Qiang Zhang Zhifei Wang Efficacy and safety of berberine for premature ventricular contractions: a meta-analysis and systematic review of randomized controlled trials Pharmaceutical Biology Coptis chinensis traditional Chinese medicine complementary alternative medicine antiarrhythmic drugs |
| title | Efficacy and safety of berberine for premature ventricular contractions: a meta-analysis and systematic review of randomized controlled trials |
| title_full | Efficacy and safety of berberine for premature ventricular contractions: a meta-analysis and systematic review of randomized controlled trials |
| title_fullStr | Efficacy and safety of berberine for premature ventricular contractions: a meta-analysis and systematic review of randomized controlled trials |
| title_full_unstemmed | Efficacy and safety of berberine for premature ventricular contractions: a meta-analysis and systematic review of randomized controlled trials |
| title_short | Efficacy and safety of berberine for premature ventricular contractions: a meta-analysis and systematic review of randomized controlled trials |
| title_sort | efficacy and safety of berberine for premature ventricular contractions a meta analysis and systematic review of randomized controlled trials |
| topic | Coptis chinensis traditional Chinese medicine complementary alternative medicine antiarrhythmic drugs |
| url | https://www.tandfonline.com/doi/10.1080/13880209.2023.2248167 |
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