Managing childhood acute lymphoblastic leukemia in a child with Emery-Dreifuss muscular dystrophy
Genetics is increasingly being integrated into clinical oncology practice. It is necessary for risk stratification of disease, for prognostication, for recognition of underlying predisposition, and for recognition of potential toxicity and predicting outcomes. The prevalence of genetic syndromes, th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2024-01-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/56842 |
| _version_ | 1797367882874617856 |
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| author | Aishvarya Diptivilasa Nita Radhakrishnan Shruti Verma |
| author_facet | Aishvarya Diptivilasa Nita Radhakrishnan Shruti Verma |
| author_sort | Aishvarya Diptivilasa |
| collection | DOAJ |
| description | Genetics is increasingly being integrated into clinical oncology practice. It is necessary for risk stratification of disease, for prognostication, for recognition of underlying predisposition, and for recognition of potential toxicity and predicting outcomes. The prevalence of genetic syndromes, their clinical significance, effect on cancer, and its treatment have been defined in recent times. In this present work, we describe the challenges we faced while managing a child with acute lymphoblastic leukemia with an underlying rare muscular dystrophy. The details were recorded from case files and prospectively collected data. Dose modification of certain chemotherapeutic drugs was planned to reduce toxicity in the child. The child responded to treatment and is currently in remission. The recognition of genetic entity and their potential interactions with treatment received for cancer is vital to plan the treatment. |
| first_indexed | 2024-03-08T17:23:32Z |
| format | Article |
| id | doaj.art-363f81cf2417435fbe7af94fc66d55cb |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-08T17:23:32Z |
| publishDate | 2024-01-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-363f81cf2417435fbe7af94fc66d55cb2024-01-03T00:54:34ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762024-01-01151272274https://doi.org/10.3126/ajms.v15i1.56842Managing childhood acute lymphoblastic leukemia in a child with Emery-Dreifuss muscular dystrophyAishvarya Diptivilasa 0Nita Radhakrishnan 1https://orcid.org/0000-0002-7941-5641Shruti Verma2Junior Resident, Department of Pediatric Hematology Oncology, Post Graduate Institute of Child Health, Noida, Uttar Pradesh, IndiaAssociate Professor, Department of Pediatric Hematology Oncology, Post Graduate Institute of Child Health, Noida, Uttar Pradesh, India IAP Fellow, Department of Pediatric Hematology Oncology, Post Graduate Institute of Child Health, Noida, Uttar Pradesh, IndiaGenetics is increasingly being integrated into clinical oncology practice. It is necessary for risk stratification of disease, for prognostication, for recognition of underlying predisposition, and for recognition of potential toxicity and predicting outcomes. The prevalence of genetic syndromes, their clinical significance, effect on cancer, and its treatment have been defined in recent times. In this present work, we describe the challenges we faced while managing a child with acute lymphoblastic leukemia with an underlying rare muscular dystrophy. The details were recorded from case files and prospectively collected data. Dose modification of certain chemotherapeutic drugs was planned to reduce toxicity in the child. The child responded to treatment and is currently in remission. The recognition of genetic entity and their potential interactions with treatment received for cancer is vital to plan the treatment.https://www.nepjol.info/index.php/AJMS/article/view/56842cancer; muscular dystrophy; cancer genetics |
| spellingShingle | Aishvarya Diptivilasa Nita Radhakrishnan Shruti Verma Managing childhood acute lymphoblastic leukemia in a child with Emery-Dreifuss muscular dystrophy Asian Journal of Medical Sciences cancer; muscular dystrophy; cancer genetics |
| title | Managing childhood acute lymphoblastic leukemia in a child with Emery-Dreifuss muscular dystrophy |
| title_full | Managing childhood acute lymphoblastic leukemia in a child with Emery-Dreifuss muscular dystrophy |
| title_fullStr | Managing childhood acute lymphoblastic leukemia in a child with Emery-Dreifuss muscular dystrophy |
| title_full_unstemmed | Managing childhood acute lymphoblastic leukemia in a child with Emery-Dreifuss muscular dystrophy |
| title_short | Managing childhood acute lymphoblastic leukemia in a child with Emery-Dreifuss muscular dystrophy |
| title_sort | managing childhood acute lymphoblastic leukemia in a child with emery dreifuss muscular dystrophy |
| topic | cancer; muscular dystrophy; cancer genetics |
| url | https://www.nepjol.info/index.php/AJMS/article/view/56842 |
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