The hematopoietic growth factors - a new perspective in the neuroprotective therapy of the ischemic stroke
The hematopoietic growth factors (HGF) have been known for 20 years, named for their role in the proliferation, differentiation and survival of hematopoietic progenitor cells. They (erythropoietin, G-CSF and GM-CSF) have been used many years in clinical practice in oncological and hematological path...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2009-12-01
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| Series: | Romanian Journal of Neurology |
| Subjects: | |
| Online Access: | https://rjn.com.ro/articles/2009.4/RJN_2009_4_Art-04.pdf |
| _version_ | 1811340594717392896 |
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| author | Dana Fodor Lacramioara Perju-Dumbrava |
| author_facet | Dana Fodor Lacramioara Perju-Dumbrava |
| author_sort | Dana Fodor |
| collection | DOAJ |
| description | The hematopoietic growth factors (HGF) have been known for 20 years, named for their role in the proliferation, differentiation and survival of hematopoietic progenitor cells. They (erythropoietin, G-CSF and GM-CSF) have been used many years in clinical practice in oncological and hematological pathology. Recent studies suggest that HGF have also important non-hematopoietic functions in the central nervous system. HGF and their receptors are expressed by neurons in many brain regions and are up-regulated after focal ischemia, indicating an autocrin protective response of the injured brain. The neuroprotective function of HGF has been suggested by the effect of decreasing infarct volumes in different experimental models in rodents and has been attributed to their anti-apoptotic activity (by activating several protective pathways, PI3K/Akt being the most important). Moreover, HGF induces neurogenesis and angiogenesis, possible the substrate of improving recovery post stroke.
There is emerging data from recent studies suggesting that EPO, G-CSF and GM-CSF are potential new agents, a novel type of multifactorial drugs and candidates for neuroprotection in ischemic stroke. Here we discuss this new property of HGF behind the known function in hematopoietic system, summarize data from literature concerning HGF’s actions in cerebral ischemia and highlight clinical implications. |
| first_indexed | 2024-04-13T18:44:17Z |
| format | Article |
| id | doaj.art-3640969a274544bebdae25bce79f9164 |
| institution | Directory Open Access Journal |
| issn | 1843-8148 2069-6094 |
| language | English |
| last_indexed | 2024-04-13T18:44:17Z |
| publishDate | 2009-12-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj.art-3640969a274544bebdae25bce79f91642022-12-22T02:34:38ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942009-12-018417417710.37897/RJN.2009.4.4The hematopoietic growth factors - a new perspective in the neuroprotective therapy of the ischemic strokeDana Fodor0Lacramioara Perju-Dumbrava1“Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania“Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaThe hematopoietic growth factors (HGF) have been known for 20 years, named for their role in the proliferation, differentiation and survival of hematopoietic progenitor cells. They (erythropoietin, G-CSF and GM-CSF) have been used many years in clinical practice in oncological and hematological pathology. Recent studies suggest that HGF have also important non-hematopoietic functions in the central nervous system. HGF and their receptors are expressed by neurons in many brain regions and are up-regulated after focal ischemia, indicating an autocrin protective response of the injured brain. The neuroprotective function of HGF has been suggested by the effect of decreasing infarct volumes in different experimental models in rodents and has been attributed to their anti-apoptotic activity (by activating several protective pathways, PI3K/Akt being the most important). Moreover, HGF induces neurogenesis and angiogenesis, possible the substrate of improving recovery post stroke. There is emerging data from recent studies suggesting that EPO, G-CSF and GM-CSF are potential new agents, a novel type of multifactorial drugs and candidates for neuroprotection in ischemic stroke. Here we discuss this new property of HGF behind the known function in hematopoietic system, summarize data from literature concerning HGF’s actions in cerebral ischemia and highlight clinical implications.https://rjn.com.ro/articles/2009.4/RJN_2009_4_Art-04.pdfhematopoietic growth factorsischemic strokeneuroprotection |
| spellingShingle | Dana Fodor Lacramioara Perju-Dumbrava The hematopoietic growth factors - a new perspective in the neuroprotective therapy of the ischemic stroke Romanian Journal of Neurology hematopoietic growth factors ischemic stroke neuroprotection |
| title | The hematopoietic growth factors - a new perspective in the neuroprotective therapy of the ischemic stroke |
| title_full | The hematopoietic growth factors - a new perspective in the neuroprotective therapy of the ischemic stroke |
| title_fullStr | The hematopoietic growth factors - a new perspective in the neuroprotective therapy of the ischemic stroke |
| title_full_unstemmed | The hematopoietic growth factors - a new perspective in the neuroprotective therapy of the ischemic stroke |
| title_short | The hematopoietic growth factors - a new perspective in the neuroprotective therapy of the ischemic stroke |
| title_sort | hematopoietic growth factors a new perspective in the neuroprotective therapy of the ischemic stroke |
| topic | hematopoietic growth factors ischemic stroke neuroprotection |
| url | https://rjn.com.ro/articles/2009.4/RJN_2009_4_Art-04.pdf |
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