2-(2-Methyl-2-nitrovinyl)furan but Not Furvina Interfere with <i>Staphylococcus aureus</i> Agr Quorum-Sensing System and Potentiate the Action of Fusidic Acid against Biofilms

2-(2-Methyl-2-nitrovinyl)furan but Not Furvina Interfere with <i>Staphylococcus aureus</i> Agr Quorum-Sensing System and Potentiate the Action of Fusidic Acid against Biofilms

Quorum sensing (QS) plays an essential role in the production of virulence factors, in biofilm formation and antimicrobial resistance. Consequently, inhibiting QS is being considered a promising target for antipathogenic/anti-virulence therapies. This study aims to screen 2-nitrovinylfuran derivativ...

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Bibliographic Details
Main Authors: Diana Oliveira, Anabela Borges, Reinaldo Molina Ruiz, Zenaida Rodríguez Negrín, Simona Distinto, Fernanda Borges, Manuel Simões
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
Furvina
2-nitrovinylfuran derivatives
<i>Staphylococcus aureus</i>
quorum-sensing inhibition
biofilms
antimicrobial combination
Online Access:https://www.mdpi.com/1422-0067/22/2/613

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