The GDF11 Promotes Nerve Regeneration After Sciatic Nerve Injury in Adult Rats by Promoting Axon Growth and Inhibiting Neuronal Apoptosis

The GDF11 Promotes Nerve Regeneration After Sciatic Nerve Injury in Adult Rats by Promoting Axon Growth and Inhibiting Neuronal Apoptosis

Introduction: Sciatic nerve injury is a common injury of the nervous system. Stem cell-based therapies, drug-based therapies and rehabilitation physiotherapy therapies are currently available, but their limited therapeutic efficacy limits their use. Here, we aimed to explore a novel lentiviral-based...

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Bibliographic Details
Main Authors: Junhao Lin, Jie Shi, Xiang Min, Si Chen, Yunpeng Zhao, Yuanqiang Zhang, Lei Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
sciatic nerve injury
nerve regeneration
lentiviral vector
growth differentiation factor 11
smad pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.803052/full

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