Immunoglobulin G genetic variation can confound assessment of antibody levels via altered binding to detection reagents

Immunoglobulin G genetic variation can confound assessment of antibody levels via altered binding to detection reagents

Abstract Objectives Amino acid variations across more than 30 immunoglobulin (Ig) allotypes may introduce structural changes that influence recognition by anti‐Ig detection reagents, consequently confounding interpretation of antibody responses, particularly in genetically diverse cohorts. Here, we...

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Bibliographic Details
Main Authors: Ruth A Purcell, L Carissa Aurelia, Robyn Esterbauer, Lilith F Allen, Katherine A Bond, Deborah A Williamson, Janine M Trevillyan, Jason A Trubiano, Jennifer J Juno, Adam K Wheatley, Miles P Davenport, Thi HO Nguyen, Katherine Kedzierska, Stephen J Kent, Kevin John Selva, Amy W Chung
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Clinical & Translational Immunology
Subjects:
allotype
anti‐immunoglobulin
IgG
polymorphisms
reproducibility
serology
Online Access:https://doi.org/10.1002/cti2.1494

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