Comparison of immunotherapy mediated by apoptotic bodies, microvesicles and exosomes: apoptotic bodies’ unique anti-inflammatory potential
Abstract Immunotherapy, including immunostimulation and immunosuppression, has seen significant development in the last 10 years. Immunostimulation has been verified as effective in anti-cancer treatment, while immunosuppression is used in the treatment of autoimmune disease and inflammation. Curren...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-023-04342-w |
| _version_ | 1797773943931666432 |
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| author | Jing Wen Dale Creaven Xiangshu Luan Jiemin Wang |
| author_facet | Jing Wen Dale Creaven Xiangshu Luan Jiemin Wang |
| author_sort | Jing Wen |
| collection | DOAJ |
| description | Abstract Immunotherapy, including immunostimulation and immunosuppression, has seen significant development in the last 10 years. Immunostimulation has been verified as effective in anti-cancer treatment, while immunosuppression is used in the treatment of autoimmune disease and inflammation. Currently, with the update of newly-invented simplified isolation methods and the findings of potent triggered immune responses, extracellular vesicle-based immunotherapy is very eye-catching. However, the research on three main types of extracellular vesicles, exosomes, microvesicles and apoptotic bodies, needs to be more balanced. These three subtypes share a certain level of similarity, and at the same time, they have their own properties caused by the different methods of biogensis. Herein, we summarized respectively the status of immunotherapy based on each kind of vesicle and discuss the possible involved mechanisms. In conclusion, we highlighted that the effect of the apoptotic body is clear and strong. Apoptotic bodies have an excellent potential in immunosuppressive and anti-inflammatory therapies . |
| first_indexed | 2024-03-12T22:13:38Z |
| format | Article |
| id | doaj.art-3642b9deaf8340929e03f6b78275593c |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-03-12T22:13:38Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-3642b9deaf8340929e03f6b78275593c2023-07-23T11:25:32ZengBMCJournal of Translational Medicine1479-58762023-07-0121111410.1186/s12967-023-04342-wComparison of immunotherapy mediated by apoptotic bodies, microvesicles and exosomes: apoptotic bodies’ unique anti-inflammatory potentialJing Wen0Dale Creaven1Xiangshu Luan2Jiemin Wang3Department of Pharmacy, The Third Hospital of ChangshaRegenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of GalwaySchool of Life Science and Technology, China Pharmaceutical UniversityRegenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of GalwayAbstract Immunotherapy, including immunostimulation and immunosuppression, has seen significant development in the last 10 years. Immunostimulation has been verified as effective in anti-cancer treatment, while immunosuppression is used in the treatment of autoimmune disease and inflammation. Currently, with the update of newly-invented simplified isolation methods and the findings of potent triggered immune responses, extracellular vesicle-based immunotherapy is very eye-catching. However, the research on three main types of extracellular vesicles, exosomes, microvesicles and apoptotic bodies, needs to be more balanced. These three subtypes share a certain level of similarity, and at the same time, they have their own properties caused by the different methods of biogensis. Herein, we summarized respectively the status of immunotherapy based on each kind of vesicle and discuss the possible involved mechanisms. In conclusion, we highlighted that the effect of the apoptotic body is clear and strong. Apoptotic bodies have an excellent potential in immunosuppressive and anti-inflammatory therapies .https://doi.org/10.1186/s12967-023-04342-wImmunotherapyImmunostimulatoryImmunomodulatoryExtracellular vesiclesApoptotic bodiesMicrovesicles |
| spellingShingle | Jing Wen Dale Creaven Xiangshu Luan Jiemin Wang Comparison of immunotherapy mediated by apoptotic bodies, microvesicles and exosomes: apoptotic bodies’ unique anti-inflammatory potential Journal of Translational Medicine Immunotherapy Immunostimulatory Immunomodulatory Extracellular vesicles Apoptotic bodies Microvesicles |
| title | Comparison of immunotherapy mediated by apoptotic bodies, microvesicles and exosomes: apoptotic bodies’ unique anti-inflammatory potential |
| title_full | Comparison of immunotherapy mediated by apoptotic bodies, microvesicles and exosomes: apoptotic bodies’ unique anti-inflammatory potential |
| title_fullStr | Comparison of immunotherapy mediated by apoptotic bodies, microvesicles and exosomes: apoptotic bodies’ unique anti-inflammatory potential |
| title_full_unstemmed | Comparison of immunotherapy mediated by apoptotic bodies, microvesicles and exosomes: apoptotic bodies’ unique anti-inflammatory potential |
| title_short | Comparison of immunotherapy mediated by apoptotic bodies, microvesicles and exosomes: apoptotic bodies’ unique anti-inflammatory potential |
| title_sort | comparison of immunotherapy mediated by apoptotic bodies microvesicles and exosomes apoptotic bodies unique anti inflammatory potential |
| topic | Immunotherapy Immunostimulatory Immunomodulatory Extracellular vesicles Apoptotic bodies Microvesicles |
| url | https://doi.org/10.1186/s12967-023-04342-w |
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